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Deep Supratentorial Extension Is Associated With Poor Clinical Outcomes After Glioblastoma Resection, Adam Barsouk, Michael P. Baldassari, Omaditya Khanna, Donald Ye, Erica Cunningham, Christopher Farrell, David Andrews, James Evans, Kevin Judy
Deep Supratentorial Extension Is Associated With Poor Clinical Outcomes After Glioblastoma Resection, Adam Barsouk, Michael P. Baldassari, Omaditya Khanna, Donald Ye, Erica Cunningham, Christopher Farrell, David Andrews, James Evans, Kevin Judy
Phase 1
Introduction: Glioblastoma (GBM) often extends to deep supratentorial locations, which limits the extent of maximal safe resection. Deep supratentorial extension (DSE) may be a clinically convenient prognostic indicator following GBM resection.
Methods: 582 GBM resections from 2012-2018 were retrospectively reviewed. DSE was defined as tumoral extension to the basal ganglia, thalamus, corpus callosum, internal capsule, hypothalamus, caudate, or putamen as identified on preoperative imaging.
Results: DSE was identified in 32.9% cases (192), while 52.5% (306) involved only superficial supratentorial locations (frontal, parietal, temporal and occipital lobes). Within the DSE cohort, the most commonly affected anatomical locations were the corpus …