Translational Medical Research Commons^™

Role Of Proteolipid Protein In Hsv-1 Entry In Oligodendrocytic Cells, Raquel Bello-Morales, Antonio Jesús Crespillo, Beatriz Praena, Enrique Tabarés, Yolanda Revilla, Elena García, Alberto Fraile-Ramos, Wia Baron, Claude Krummenacher, José Antonio López-Guerrero

Faculty Scholarship for the College of Science & Mathematics

Herpes simplex virus type 1 (HSV-1) has the ability to enter many different hosts and cell types by several strategies. This highly prevalent alphaherpesvirus can enter target cells using different receptors and different pathways: fusion at a neutral pH, low-pH-dependent and low-pH-independent endocytosis. Several cell receptors for viral entry have been described, but several observations suggest that more receptors for HSV-1 might exist. In this work, we propose a novel role for the proteolipid protein (PLP) in HSV-1 entry into the human oligodendrocytic cell line HOG. Cells transfected with PLP-EGFP showed an increase in susceptibility to HSV-1. Furthermore, the infection …