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Full-Text Articles in Translational Medical Research
Statistics Of Tumor Micro-Environment, Brenton Maisel, Inna Chervoneva
Statistics Of Tumor Micro-Environment, Brenton Maisel, Inna Chervoneva
Phase 1
Introduction: Immune cells play a prominent role in keeping tumors suppressed, but how the distribution of these immune cells within a tumor’s microenvironment remains poorly understood. The long-term goal of this project is to study how statistical spatial distributions of different immune cells is associated with clinical outcome. The first objective is developing an algorithm for identifying different types of immune cells.
Methods: The data motivating this project includes spatial localization information (x-y coordinates) and expression levels of immune cell CD markers quantified by immunofluorescence immunohistochemistry (IF-IHC) in ~1,500 cases of invasive breast cancer. Using expression levels of CD markers …