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Marked Circadian Variation In Number And Type Of Hyperacute Strokes During The 24 Hour Day-Night Cycle, Eeman Khorramian, Sidney Starkman, Nerses Sanossian, David Liebeskind, Gilda Avila, Samuel Stratton, Marc Eckstein, Frank Pratt, Latisha Sharma, Lucas Restrepo, Miguel Valdes-Sueiras, May Kim-Tenser, Pablo Villablanca, Robin Conwit, Scott Hamilton, Jeffrey L. Saver, Fast-Mag Trial Investigators And Coordinators

Phase 1

Introduction: Circadian variations in stroke onset provide critical information for the allocation of pre-hospital and hospital resources in clinical care. Confining analysis to patients with defined onset in waking and clearly distinguished ischemic and hemorrhagic stroke subtypes, would substantial benefit our understanding of stroke etiology.

Methods: We analyzed patients enrolled in the NIH FAST-MAG phase 3 trial of field-initiated neuroprotective agents in patients with hyperacute stroke within 2h of onset. Onset times were analyzed in 1h time blocks throughout the 24h day-night cycle. Patient demographic and clinical features, medical history, imaging characteristics, and stroke deficit severity were correlated with …