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Full-Text Articles in Sports Sciences
Bioactive Growth Hormone In Humans: Controversies, Complexities And Concepts, Wesley C. Hymer, Mary J. Kennett, Samir K. Maji, Kristin L. Gosselink, Gary E. Mccall, Richard E. Grindeland, Emily M. Post, William J. Kramer
Bioactive Growth Hormone In Humans: Controversies, Complexities And Concepts, Wesley C. Hymer, Mary J. Kennett, Samir K. Maji, Kristin L. Gosselink, Gary E. Mccall, Richard E. Grindeland, Emily M. Post, William J. Kramer
Health and Sport Sciences Faculty Scholarship
Objective: To revisit a finding, first described in 1978, which documented existence of a pituitary growth factor that escaped detection by immunoassay, but which was active in the established rat tibia GH bioassay.
Methods: We present a narrative review of the evolution of growth hormone complexity, and its bio-detectability, from a historical perspective.
Results: In humans under the age of 60, physical training (i.e. aerobic endurance and resistance training) are stressors which preferentially stimulate release of bioactive GH (bGH) into the blood. Neuroanatomical studies indicate a) that nerve fibers directly innervate the human anterior pituitary and b) that hind limb …
Bioactive Growth Hormone In Older Men And Women: Its Relationship To Immune Markers And Healthspan, William J. Kraemer, Mary J. Kennett, Andrea M. Mastro, Roger J. Mccarter, Connie J. Rogers, William H. Dupont, Shawn D. Flanagan, William J. Turbitt, Maren S. Fragala, Emily M. Post, Wesley C. Hymer
Bioactive Growth Hormone In Older Men And Women: Its Relationship To Immune Markers And Healthspan, William J. Kraemer, Mary J. Kennett, Andrea M. Mastro, Roger J. Mccarter, Connie J. Rogers, William H. Dupont, Shawn D. Flanagan, William J. Turbitt, Maren S. Fragala, Emily M. Post, Wesley C. Hymer
Health and Sport Sciences Faculty Scholarship
Objective: The consequences of age-related decline in the somatotropic axis of humans are complex and remain largely unresolved. We tested the hypothesis that hGH measurements of plasma by bioassay vs immunoassay from samples obtained from free-living, elderly individuals would reveal a dichotomy in GH activities that are correlated with the functional status of the donors, i.e. their healthspan.
Design: Forty-one men and women of advanced age (men: N=16, age, 80.5±6.5years; height, 173.1±6.9cm; body mass, 81.8±13.0kg) and (women: N=25, age, 80.7±7.2years; height, 157.7±6.0cm; body mass, 68.8±17kg), were recruited for a cross-sectional study. Participants filled out PROMIS (Patient-Reported Outcomes Measurement Information System, …