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Atypical Antipsychotic Drugs And The Risk Of Acute Kidney Injury: A Population-Based Cohort Study, Yoseob Joseph Hwang
Atypical Antipsychotic Drugs And The Risk Of Acute Kidney Injury: A Population-Based Cohort Study, Yoseob Joseph Hwang
Electronic Thesis and Dissertation Repository
Older adults are frequently prescribed atypical antipsychotic drugs and may be at a risk for kidney-related adverse events. This population-based retrospective cohort study examined the 90-day risk of acute kidney injury (AKI) and the potential reasons for AKI in 96,471 matched pairs of older adults who received and who did not receive a new atypical antipsychotic drug prescription from 2003 to 2011 in Ontario. Atypical antipsychotic drug use was associated with a higher risk of hospitalization with AKI (relative risk (RR) 2.06 [95% confidence interval (CI) 1.85–2.29]). The drug use was also associated with potential reasons for AKI including hypotension …