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Full-Text Articles in Public Health

Detection Of Heterogeneity Of Borrelia Burgdorferi In Ixodes Ticks By Culture-Dependent And Culture-Independent Methods, Guang Xu, Jaime Wesker, Caitlin White, Jason Campbell, Nicholas G. Reich, Stephen M. Rich Jan 2013

Detection Of Heterogeneity Of Borrelia Burgdorferi In Ixodes Ticks By Culture-Dependent And Culture-Independent Methods, Guang Xu, Jaime Wesker, Caitlin White, Jason Campbell, Nicholas G. Reich, Stephen M. Rich

Nicholas G Reich

Abilities to detect heterogeneity of ospC genotypes of the Lyme disease spirochete Borrelia burgdorferi in the tick vector by in vitro culture (IVC) and direct PCR (dPCR) were compared. IVC failed to detect one-third of the ospC genotypes detected by dPCR. Among IVC results, common ospC genotypes were overrepresented while occurrence of rare genotypes was underestimated.


Incubation Periods Of Viral Gastroenteritis: A Systematic Review, Rachel M. Lee, Justin Lessler, Rose A. Lee, Kara E. Rudolph, Nicholas G. Reich, Trish M. Perl, Derek A. T. Cummings Dec 2012

Incubation Periods Of Viral Gastroenteritis: A Systematic Review, Rachel M. Lee, Justin Lessler, Rose A. Lee, Kara E. Rudolph, Nicholas G. Reich, Trish M. Perl, Derek A. T. Cummings

Nicholas G Reich

Background: Accurate knowledge of incubation period is important to investigate and to control infectious diseases and their transmission, however statements of incubation period in the literature are often uncited, inconsistent, and/or not evidence based. Methods: In a systematic review of the literature on five enteric viruses of public health importance, we found 256 articles with incubation period estimates, including 33 with data for pooled analysis. Results: We fit a log-normal distribution to pooled data and found the median incubation period to be 4.5 days (95% CI 3.9-5.2 days) for astrovirus, 1.2 days (95% CI 1.1-1.2 days) for norovirus genogroups I …