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Molecular Typing Of Rickettsia Akari, Marina E. Eremeeva
Molecular Typing Of Rickettsia Akari, Marina E. Eremeeva
Department of Biostatistics, Epidemiology, and Environmental Health Sciences Faculty Publications
Rickettsia akari is an obligate intracellular bacterium that causes smallpox rickettsia. Rickettsia akari is an atypical member of the rickettsia spotted fever (SFG) group because it circulates in gamasid mites; however, only limited data are available regarding the degree of genetic diversity of R. akari isolates. We examined 13 isolates of R. akari isolated from humans, rodents, and ticks in the United States, the countries of the former USSR, and the former Yugoslavia for the period from 1946 to 2003 for diversity in the composition of tandem repeats (TR) and intergenic regions (IGR). Using the Tandem Repeat Finder software (http://tandem.bu.edu) …
Rickettsialpox – A Rare But Not Extinct Disease: A Review Of The Literature And New Directions, Marina Eremeeva, Kamalich Muniz-Rodriguez
Rickettsialpox – A Rare But Not Extinct Disease: A Review Of The Literature And New Directions, Marina Eremeeva, Kamalich Muniz-Rodriguez
Department of Biostatistics, Epidemiology, and Environmental Health Sciences Faculty Publications
Smallpox rickettsia is an urban zoonosis caused by Rickettsia akari. To date, R. akari is the only characterized representative of the group of spotted fevers transmitted by the gamasid mite Liponyssoides sanguineus, which is common among peridomic rodents. This disease was first described in New York in 1946, and a few years later a similar outbreak occurred in the Ukrainian SSR. Numerous serological studies and diagnostics of sporadic cases of smallpox rickettsiosis suggest its widespread occurrence on the planet; however, the current geography and incidence of smallpox rickettsiosis is unknown. Smallpox rickettsiosis is characterized by the classic clinical triad of …
Challenges Posed By Tick-Borne Rickettsiae: Eco- Epidemiology And Public Health Implications, Marina E. Eremeeva, Gregory A. Dasch
Challenges Posed By Tick-Borne Rickettsiae: Eco- Epidemiology And Public Health Implications, Marina E. Eremeeva, Gregory A. Dasch
Environmental Health Sciences Faculty Publications
Rickettsiae are obligately intracellular bacteria that are transmitted to vertebrates by a variety of arthropod vectors, primarily by fleas and ticks. Once transmitted or experimentally inoculated into susceptible mammals, some rickettsiae may cause febrile illness of different morbidity and mortality, and which can manifest with different types of exhanthems in humans. However, most rickettsiae circulate in diverse sylvatic or peridomestic reservoirs without having obvious impacts on their vertebrate hosts or affecting humans. We have analyzed the key features of tick-borne maintenance of rickettsiae, which may provide a deeper basis for understanding those complex invertebrate interactions and strategies that have permitted …