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Full-Text Articles in Public Health
Altered Folate Availability Modifies The Molecular Environment Of The Human Colon: Implications For Colorectal Carcinogenesis, Petr Protiva, Joel B. Mason, Zhenhua Liu, Michael E. Hopkins, Celeste Nelson, James R. Marshall, Richard W. Lambrecht, Swaroop Pendyala, Levy Kopelovich, Myungjin Kim, Steven H. Kleinstein, Peter W. Laird, Martin Lipkin, Peter R. Holt
Altered Folate Availability Modifies The Molecular Environment Of The Human Colon: Implications For Colorectal Carcinogenesis, Petr Protiva, Joel B. Mason, Zhenhua Liu, Michael E. Hopkins, Celeste Nelson, James R. Marshall, Richard W. Lambrecht, Swaroop Pendyala, Levy Kopelovich, Myungjin Kim, Steven H. Kleinstein, Peter W. Laird, Martin Lipkin, Peter R. Holt
Zhenhua Liu
BACKGROUND—Low folate status increases colorectal cancer risk whereas abundant supplementation may paradoxically increase risk. The mechanisms are unknown. OBJECTIVES—To define molecular pathways in the human colon altered by either dietary folate depletion (followed by repletion), or by supplementation. METHODS—10 healthy volunteers consumed a low folate diet for 12 weeks. During the last 4 weeks, folic acid (1 mg/day) was administered. In a second study, 10 other subjects were provided supplemental folic acid for 8 weeks. Rectosigmoid biopsies were obtained at measured intervals in both studies for assessment of primary endpoints: genome-wide gene expression, genomic DNA methylation, promoter methylation (depletion study …
Associations Of Plasma Selenium With Arsenic And Genomic Methylation Of Leukocyte Dna In Bangladesh, Richard J. Pilsner, Megan N. Hall, Xinhua Liu, Habibul Ahsan, Vesna Ilievski, Vesna Slavkovich, Diane Levy, Pam Factor-Litvak, Joseph H. Graziano, Mary V. Gamble
Associations Of Plasma Selenium With Arsenic And Genomic Methylation Of Leukocyte Dna In Bangladesh, Richard J. Pilsner, Megan N. Hall, Xinhua Liu, Habibul Ahsan, Vesna Ilievski, Vesna Slavkovich, Diane Levy, Pam Factor-Litvak, Joseph H. Graziano, Mary V. Gamble
J. Richard Pilsner
Background
Global hypomethylation of DNA is thought to constitute an early event in some cancers and occurs in response to arsenic (As) exposure and/or selenium (Se) deficiency in both in vitro and animal models. In addition, antagonism between As and Se, whereby each reduces toxicity of the other, has been well documented in animal models. Se status may therefore modify the health effects of As in As-exposed populations.
Objective
The primary objectives of our study were to test the hypothesis that Se deficiency is associated with genomic hypomethylation of lymphocyte DNA and to determine whether Se levels are associated with …