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Full-Text Articles in Public Health
Nondense Mammographic Area And Risk Of Breast Cancer, Andreas Pettersson, Susan E. Hankinson, Walter C. Willett, Pagona Lagiou, Dimitrios Trichopoulos, Rulla M. Tamimi
Nondense Mammographic Area And Risk Of Breast Cancer, Andreas Pettersson, Susan E. Hankinson, Walter C. Willett, Pagona Lagiou, Dimitrios Trichopoulos, Rulla M. Tamimi
Susan E. Hankinson
Introduction The mechanisms underlying the strong association between percentage dense area on a mammogram and the risk of breast cancer are unknown. We investigated separately the absolute dense area and the absolute nondense area on mammograms in relation to breast cancer risk. Methods We conducted a nested case-control study on prediagnostic mammographic density measurements and risk of breast cancer in the Nurses' Health Study and the Nurses' Health Study II. Premenopausal mammograms were available from 464 cases and 998 controls, and postmenopausal mammograms were available from 960 cases and 1,662 controls. We used a computer-assisted thresholding technique to measure mammographic …
Plasma 25-Hydroxyvitamin D And Risk Of Breast Cancer In The Nurses' Health Study Ii, A. Heather Eliassen, Donna Spiegelman, Bruce W. Hollis, Ronald L. Horst, Walter C. Willett, Susan E. Hankinson
Plasma 25-Hydroxyvitamin D And Risk Of Breast Cancer In The Nurses' Health Study Ii, A. Heather Eliassen, Donna Spiegelman, Bruce W. Hollis, Ronald L. Horst, Walter C. Willett, Susan E. Hankinson
Susan E. Hankinson
Introduction Experimental evidence indicates vitamin D may play an important role in breast cancer etiology but epidemiologic evidence to date is inconsistent. Vitamin D comes from dietary intake and sun exposure and plasma levels of 25-hydroxyvitamin D (25(OH)D) are considered the best measure of vitamin D status. Methods We conducted a prospective nested case-control study within the Nurses' Health Study II (NHSII). Plasma samples collected in 1996 to 1999 were assayed for 25(OH)D in 613 cases, diagnosed after blood collection and before 1 June 2007, and in 1,218 matched controls. Multivariate relative risks (RR) and 95% confidence intervals (CI) were …