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A Computational Model For Analysis Of Uncoupled No Synthase On Nitric Oxide And Superoxide Interaction In Microcirculation, William Richardson, Mahendra Kavdia
A Computational Model For Analysis Of Uncoupled No Synthase On Nitric Oxide And Superoxide Interaction In Microcirculation, William Richardson, Mahendra Kavdia
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
Nitric oxide (NO) produced by endothelial cells is a key component for blood-vessel dilation. Dilation is achieved through smooth muscle relaxation as a response to NO transport. Inhibition of this process occurs through the inactivation of NO by reactive oxygen species, especially superoxide (O2 -). NO and superoxide react quickly, forming peroxynitrite (ONOO-). Both superoxide and peroxynitrite apply oxidative stress on vascular tissue. Experimental studies investigating NO interactions are difficult since these reactions occur rapidly and over small distances. This study presents a computational model to describe the interactions of NO, superoxide, and peroxynitrite across an arteriole/venule pair. Based on …