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Fate Of Registered Studies From London, Ontario, Alex Bi

Electronic Thesis and Dissertation Repository

Introduction: Lack of study publication leads to bias in the scientific literature. It is important to better understand this phenomenon and find methods for mitigation.

Research Question: How many clinical trials registered on ClinicalTrials.gov in London, Ontario are started, completed, and published?

Methods: Data from all studies in the ClinicalTrials.gov registry associated with London, Ontario were collected, from registry conception until the end of 2017. We determined whether these registered studies were published by July 2020 and whether their first publication included their planned primary outcome at all. Main factors associated with non-publication were assessed using multivariable log-binomial regression. Multivariable …