Open Access. Powered by Scholars. Published by Universities.®
Biochemical Phenomena, Metabolism, and Nutrition
- Keyword
-
- APOA2 (1)
- Adult (1)
- Aged (1)
- Branched-chain amino acid metabolism (1)
- Cancer (1)
-
- Cross-Sectional Studies (1)
- Epigenomics (1)
- Female (1)
- Gene-diet interaction (1)
- Hospital Mortality (1)
- Hospitalization (1)
- Humans (1)
- In-hospital mortality (1)
- Inpatient outcomes (1)
- Male (1)
- Metabolic Syndrome (1)
- Metabolic syndrome (1)
- Metabolomics (1)
- Middle Aged (1)
- Neoplasms (1)
- Obesity (1)
- Obesity, Morbid (1)
- Patient Discharge (1)
- Postoperative Complications (1)
- Prognosis (1)
- Satiety (1)
- Transcription (1)
- Tryptophan metabolism (1)
Articles 1 - 2 of 2
Full-Text Articles in Public Health
Epigenomics And Metabolomics Reveal The Mechanism Of The Apoa2-Saturated Fat Intake Interaction Affecting Obesity, Chao-Qiang Lai, Caren E. Smith, Laurence D. Parnell, Yu-Chi Lee, Dolores Corella, Paul Hopkins, Bertha A. Hidalgo, Stella Aslibekyan, Michael A. Province, Devin Absher, Donna K. Arnett, Katherine L. Tucker, Jose M. Ordovas
Epigenomics And Metabolomics Reveal The Mechanism Of The Apoa2-Saturated Fat Intake Interaction Affecting Obesity, Chao-Qiang Lai, Caren E. Smith, Laurence D. Parnell, Yu-Chi Lee, Dolores Corella, Paul Hopkins, Bertha A. Hidalgo, Stella Aslibekyan, Michael A. Province, Devin Absher, Donna K. Arnett, Katherine L. Tucker, Jose M. Ordovas
Epidemiology and Environmental Health Faculty Publications
Background: The putative functional variant −265T > C (rs5082) within the APOA2 promoter has shown consistent interactions with saturated fatty acid (SFA) intake to influence the risk of obesity.
Objective: The aim of this study was to implement an integrative approach to characterize the molecular basis of this interaction.
Design: We conducted an epigenome-wide scan on 80 participants carrying either the rs5082 CC or TT genotypes and consuming either a low-SFA (< 22 g/d) or high-SFA diet (≥ 22 g/d), matched for age, sex, BMI, and diabetes status in the Boston Puerto Rican Health Study (BPRHS). We then validated the findings in selected participants in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study (n = 379) and the Framingham Heart Study (FHS) (n = 243). Transcription and metabolomics analyses were conducted to determine the relation between epigenetic status, APOA2 mRNA expression, …
In-Hospital Mortality And Post-Surgical Complications Among Cancer Patients With Metabolic Syndrome, Tomi Akinyemiju, Swati Sakhuja, Neomi Vin-Raviv
In-Hospital Mortality And Post-Surgical Complications Among Cancer Patients With Metabolic Syndrome, Tomi Akinyemiju, Swati Sakhuja, Neomi Vin-Raviv
Epidemiology and Environmental Health Faculty Publications
Background
Metabolic syndrome (MetS) is an important etiologic and prognostic factor for cancer, but few studies have assessed hospitalization outcomes among patients with both conditions.
Methods
Data was obtained from the Healthcare Cost and Utilization project Nationwide Inpatient Sample (HCUP-NIS). Study variables were assessed using ICD-9 codes on adults aged 40 years and over admitted to a US hospital between 2007 and 2011 with primary diagnosis of either breast, colorectal, or prostate cancer. We examined in-hospital mortality, post-surgical complications, and discharge disposition among cancer patients with MetS and compared with non-MetS patients.
Results
Hospitalized breast (OR: 0.31, 95% CI: 0.20–0.46), …