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Full-Text Articles in Psychiatry and Psychology
An Animal Model Of The Motivational Symptoms Of Depression: Testing The Antidepressant Desipramine On An Effort-Related Choice Task, Samantha L. Collins
An Animal Model Of The Motivational Symptoms Of Depression: Testing The Antidepressant Desipramine On An Effort-Related Choice Task, Samantha L. Collins
Honors Scholar Theses
Patients with depression, schizophrenia, and other related disorders often show effort-related motivational symptoms such as anergia, psychomotor slowing, lassitude, and fatigue. Several studies have indicated that dopamine (DA) within the nucleus accumbens (NAc) is involved in the regulation of effort-related behavior. Interference with NAc DA alters response allocation in effort related choice procedures, biasing animals towards the alterative that can be obtained with minimal effort. Previous studies have shown that administration of the vesicular monoamine transporter-2 (VMAT-2) inhibitor tetrabenazine (TBZ) shifts behavior in rats responding on the FR5/chow choice procedure causing a decrease in lever pressing and a compensatory increase …