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2015

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Full-Text Articles in Psychiatry and Psychology

Neurologists Look At Causes Of Baffling Brain Condition, Maggie Freleng Dec 2015

Neurologists Look At Causes Of Baffling Brain Condition, Maggie Freleng

Capstones

It can be hard getting help for someone with mental illness, but almost impossible when that person doesn't think they are sick. At at least half of people with schizophrenia, for example, insist that the voices they hear are real. People who do not know they are ill often refuse therapy and medication -- and their symptoms can spiral out of control. Doctors call this lack of awareness anosognosia. Neurologists are trying to discover what causes this baffling condition--and how to treat it.


Association Between Depression And Aggression In Rural Women, Laetitia Meyrueix, Gabriel Durham, Jasmine Miller, K. Bryant Smalley Phd, Psyd, Jacob C. Warren Phd Dec 2015

Association Between Depression And Aggression In Rural Women, Laetitia Meyrueix, Gabriel Durham, Jasmine Miller, K. Bryant Smalley Phd, Psyd, Jacob C. Warren Phd

Journal of Health Disparities Research and Practice

Rural women represent approximately 20% of women living in the United States, yet research on the specific mental health needs of rural women is limited. Given the well-recognized gender-linked disparity in depression, its correlated symptoms in women still need much investigation. While emerging notions of depression in men embrace potential symptoms related to irritability and aggression, less research has focused on the potential role of aggression in depressed women. This connection may be particularly relevant for rural women who face unique mental health stressors in comparison to their urban counterparts. The purpose of this study was to examine if aggression …


What Does Recent Neuroscience Tell Us About Criminal Responsibility?, Uri Maoz, Gideon Yaffe Dec 2015

What Does Recent Neuroscience Tell Us About Criminal Responsibility?, Uri Maoz, Gideon Yaffe

Psychology Faculty Articles and Research

A defendant is criminally responsible for his action only if he is shown to have engaged in a guilty act—actus reus (eg for larceny, voluntarily taking someone else’s property without permission)—while possessing a guilty mind—mens rea (eg knowing that he had taken someone else’s property without permission, intending not to return it)—and lacking affirmative defenses (eg the insanity defense or self-defense). We therefore first review neuroscientific studies that bear on the nature of voluntary action, and so could, potentially, tell us something of importance about the actus reus of crimes.Then we look at studies of intention, perception of …


Examining The Connection Between Spirituality And Embodiment In Medical Education, Katie Bellamy Dec 2015

Examining The Connection Between Spirituality And Embodiment In Medical Education, Katie Bellamy

Creative Arts Therapies Theses

The purpose of this study was to explore and analyze the experience of spirituality for students of Western medicine as reflected in writing assignments for an elective course on embodiment and empathy building skills. Questions included: What is the relationship between embodiment and spirituality for students of Western medicine? How does (re-)embodiment lead to reflections on spirituality? Does mind-body awareness lead to mind-body-spirit awareness? How can incorporation of embodiment techniques into physician training foster spirituality as it relates to physicians’ professional healing roles? Based in a constructivist paradigm, this study used a qualitative grounded theory methodology to generate theory about …


Prescription For Critical Thinking: A Discussion Of Psychotropic Medication And Counseling, Barton W. Biggs Dec 2015

Prescription For Critical Thinking: A Discussion Of Psychotropic Medication And Counseling, Barton W. Biggs

Educational Specialist, 2009-2019

This paper examines questions about the safety and efficacy of psychotropic medication, and looks at how these questions should impact the field of counseling. The paper first looks at increasing rates of use of psychotropic medication, and establishes that nearly every clinical mental health counselor will work with clients who are taking or considering taking such medication. The paper next examines the scientific literature and establishes that there is a legitimate basis for questions to be raised about the safety and efficacy of these medications. The paper goes on to establish that there is a foundation in ethical codes and …


The Happy Older Latinos Are Active (Hola) Health Promotion And Prevention Study: Study Protocol For A Pilot Randomized Controlled Trial, Daniel E. Jimenez, Charles F. Reynolds, Margarita Alegría, Philip Harvey, Stephen Bartels Dec 2015

The Happy Older Latinos Are Active (Hola) Health Promotion And Prevention Study: Study Protocol For A Pilot Randomized Controlled Trial, Daniel E. Jimenez, Charles F. Reynolds, Margarita Alegría, Philip Harvey, Stephen Bartels

Dartmouth Scholarship

Results of previous studies attest to the greater illness burden of common mental disorders (anxiety and depression) in older Latinos and the need for developing preventive interventions that are effective, acceptable, and scalable. Happy Older Latinos are Active (HOLA) is a newly developed intervention that uses a community health worker (CHW) to lead a health promotion program in order to prevent common mental disorders among at-risk older Latinos. This pilot study tests the feasibility and acceptability of delivering HOLA to older, at-risk Latinos.

Methods/Design: HOLA is a multi-component, health promotion intervention funded by the National Institute of Mental Health (NIMH). …


Ubu-Unique But United: A Movement-Based Curriculum For An Inclusive Pre-School Classroom Focusing On Social-Emotional Learning, Julie Schadeck Dec 2015

Ubu-Unique But United: A Movement-Based Curriculum For An Inclusive Pre-School Classroom Focusing On Social-Emotional Learning, Julie Schadeck

Creative Arts Therapies Theses

The purpose of this program development is to address the problem of true inclusion by focusing on the role of the body and movement in social-emotional learning (SEL) among pre-school children. Every year, millions of 3 to 4 year old children leave the safe cradle of their home and embark on a life-long journey of discovery where they soon find out that not everyone is like them. To teach them that different does not mean necessarily separate, I used the University of Wisconsin Cooperative Extension logic model to develop a movement-based curriculum for an inclusive pre-school classroom focusing on SEL. …


Semantic Integration In Adults With Nonverbal Learning Disabilities And Autism Spectrum Disorder: Influence Of Word Knowledge And Gestalt Perception, Margot E. Stothers Dec 2015

Semantic Integration In Adults With Nonverbal Learning Disabilities And Autism Spectrum Disorder: Influence Of Word Knowledge And Gestalt Perception, Margot E. Stothers

Electronic Thesis and Dissertation Repository

Language in individuals with nonverbal learning disabilities (NLD) and autism spectrum disorder (ASD) has been described as semantically empty and impoverished, despite apparently average word knowledge. Here, inter-related studies explored semantic representations in adults with these disorders of social perception. Studies highlighted semantic integration, a form of gestalt perception in which new concepts are developed by connecting familiar terms in novel ways. Semantic integration was compared to vocabulary breadth, and to nonverbal gestalt perception, comparing clinical groups to each other and to adults without a diagnosis. Because weaknesses in gestalt perception have been seen in NLD and ASD, it was …


Nucleus Accumbens Deep Brain Stimulation In A Rat Model Of Binge Eating, W. T. Doucette, J. Y. Khokhar, A. I. Green Dec 2015

Nucleus Accumbens Deep Brain Stimulation In A Rat Model Of Binge Eating, W. T. Doucette, J. Y. Khokhar, A. I. Green

Dartmouth Scholarship

Binge eating (BE) is a difficult-to-treat behavior with high relapse rates, thus complicating several disorders including obesity. In this study, we tested the effects of high-frequency deep brain stimulation (DBS) in a rodent model of BE. We hypothesized that BE rats receiving high-frequency DBS in the nucleus accumbens (NAc) core would have reduced binge sizes compared with sham stimulation in both a 'chronic BE' model as well as in a 'relapse to chronic BE' model. Male Sprague-Dawley rats (N=18) were implanted with stimulating electrodes in bilateral NAc core, and they received either active stimulation (N=12) or sham stimulation (N=6) for …


Adhd And Social Impairment Among Children: Problem Solving Skills As A Potential Mediator, Rebecca Mccord Dec 2015

Adhd And Social Impairment Among Children: Problem Solving Skills As A Potential Mediator, Rebecca Mccord

Senior Theses

This study tested the hypothesis that problem solving skills mediate the relation between ADHD symptoms and social impairment in children. Problem solving skills were evaluated by the Test of Problem Solving 3 – Elementary Version (TOPS), which separated problem solving skills into six different subtypes: making inferences, sequencing, negative questions, problem solving, predicting, and determining causes. ADHD symptoms were assessed through the parent report of the Disruptive Behavior Disorder Scale (DBD). Social impairment was assessed through the parent report of social skills using the Social Skills Improvement System (SSIS). Three hundred seventy-two (372) children between the ages of eight and …


Smoking And Exercise: Mechanisms And Effects During Simulated And Genuine Quit Attempts, Stefanie De Jesus Dec 2015

Smoking And Exercise: Mechanisms And Effects During Simulated And Genuine Quit Attempts, Stefanie De Jesus

Electronic Thesis and Dissertation Repository

Cigarette smoking is a leading agent for premature morbidity and mortality among the global community. Most individuals surrender to tobacco use disorder due to the inability to cope with cravings and withdrawal symptoms. Exercise appears to provide acute relief. Currently, it is unclear how exercise attenuates these reductions. Furthermore, the available evidence has focused on acute outcomes besides smoking behaviour and is limited to simulated quit attempts. Three experimental studies were designed to address these outstanding issues. Not surprisingly, a bout of moderate intensity exercise was found in study 1 (chapter 2) to reduce cravings associated with a temporary period …


Effects Of Repeated Quetiapine Treatment On Conditioned Avoidance Responding In Rats, Jun Gao, Min Feng, Natashia Swalve, Collin Davis, Nan Sui, Ming Li Dec 2015

Effects Of Repeated Quetiapine Treatment On Conditioned Avoidance Responding In Rats, Jun Gao, Min Feng, Natashia Swalve, Collin Davis, Nan Sui, Ming Li

Department of Psychology: Faculty Publications

The present study characterized the behavioral mechanisms of avoidance–disruptive effect of quetiapine in the conditioned avoidance response test under two behavioral testing (2 warning signals vs. 1 warning signal) and two drug administration conditions (subcutaneous vs. intravenous). In Experiments 1 and 2, well-trained adult male Sprague-Dawley rats were tested under the subcutaneous (s.c.) quetiapine treatment (5.0, 15.0, 25.0, 50.0 mg/kg) for 7 days in a novel procedure consisting of two conditioned stimuli (CS) (white noise serving as CS1 and pure tone as CS2). Only the highest dose (50.0 mg/kg) produced a persistent suppression of the avoidance response without impairing the …


The Visual Priming Of Motion-Defined 3d Objects, Xiong Jiang, Yang Jiang, Raja Parasuraman Dec 2015

The Visual Priming Of Motion-Defined 3d Objects, Xiong Jiang, Yang Jiang, Raja Parasuraman

Behavioral Science Faculty Publications

The perception of a stimulus can be influenced by previous perceptual experience, a phenomenon known as perceptual priming. However, there has been limited investigation on perceptual priming of shape perception of three-dimensional object structures defined by moving dots. Here we examined the perceptual priming of a 3D object shape defined purely by motion-in-depth cues (i.e., Shape-From-Motion, SFM) using a classic prime-target paradigm. The results from the first two experiments revealed a significant increase in accuracy when a "cloudy" SFM stimulus (whose object structure was difficult to recognize due to the presence of strong noise) was preceded by an unambiguous SFM …


The Hidden Epidemic: Mental Health Epidemiology In Post-Conflict Populations And Implications For Conflict Transformation Practices, Jennifer Sato Dec 2015

The Hidden Epidemic: Mental Health Epidemiology In Post-Conflict Populations And Implications For Conflict Transformation Practices, Jennifer Sato

Capstone Collection

This capstone explores the ramifications of unmitigated mental health illness in conflict populations, paying special attention to refugees and migrants. The intersection between conflict and mental health is explored and analyzed in order to highlight the implications of the findings and to make recommendations to both metal health and conflict transformation practitioners. This capstone depends predominately on secondary resources and personal interviews and is informed by my own practicum experience at a refugee health center. The need to improve mental health outcomes in order to pursue conflict transformation and peace building is a key focus and is supported by the …


Searching For Connection: A Heuristic Study Of The Role Of Consciousness In Identifying And Meeting Human Needs Through Expressive Movement, Amy Leow Dec 2015

Searching For Connection: A Heuristic Study Of The Role Of Consciousness In Identifying And Meeting Human Needs Through Expressive Movement, Amy Leow

Creative Arts Therapies Theses

The purpose of this study was to draw initial conclusions regarding the relationships between expressive movement, consciousness, and human needs. Additionally, this study also aimed to illustrate how the process of shifting conscious awareness through expressive movement enables clients of DMT to identify and meet their needs. Data was collected using a heuristic examination of my own experience, as the only participant of this study, engaging in six Authentic Movement sessions over six weeks. Data analysis, using a heuristic methodology, resulted in several conclusions which piece together an initial framework from which to understand how the process of shifting conscious …


Sedation And Disruption Of Maternal Motivation Underlie The Disruptive Effects Of Antipsychotic Treatment On Rat Maternal Behavior, Changjiu Zhao, Ming Li Dec 2015

Sedation And Disruption Of Maternal Motivation Underlie The Disruptive Effects Of Antipsychotic Treatment On Rat Maternal Behavior, Changjiu Zhao, Ming Li

Ming Li

The behavioral mechanisms underlying antipsychotic-induced maternal behavior deficits were examined in the present study. Different groups of postpartum rats were treated with haloperidol (0.1 mg/kg), clozapine (10.0 mg/kg), chlordiazepoxide (5.0 mg/kg, an anxiolytic) or vehicle (0.9% saline) on Days 4 and 6 postpartum and their maternal behaviors were tested under either pup-separation (e.g. pups were removed from their mothers for 4 h before testing) or no-pup-separation condition. Maternal behavior and drug-induced sedation were further tested for 3 days from Day 8 to 12 postpartum. Results show that pup-separation, which putatively increases maternal motivation, did significantly shorten clozapine-elongated pup approach latency, …


Evening Snacking In Relation To Self-Reported Declines In Sleep Quality During Pregnancy: Preliminary Results From The Decision-Making, Eating, And Weight Gain During Pregnancy (Dew) Study, Wendy Mccallum, Bradley M. Appelhans, Tiffany A. Moore Simas, Rui Sherry Xiao, Shums Alikhan, Isabelle C. Pierre-Louis, Barbara C. Olendzki, Sherry L. Pagoto, Molly E. Waring Dec 2015

Evening Snacking In Relation To Self-Reported Declines In Sleep Quality During Pregnancy: Preliminary Results From The Decision-Making, Eating, And Weight Gain During Pregnancy (Dew) Study, Wendy Mccallum, Bradley M. Appelhans, Tiffany A. Moore Simas, Rui Sherry Xiao, Shums Alikhan, Isabelle C. Pierre-Louis, Barbara C. Olendzki, Sherry L. Pagoto, Molly E. Waring

Tiffany A. Moore Simas

Background: Poor sleep in non-pregnant adults has been associated with increased evening snacking, which may contribute to weight gain. Sleep disturbances are common during pregnancy.

Objective: To examine the association between changes in sleep quality from pre-pregnancy and evening snacking.

Methods: In an ongoing prospective cohort study, pregnant women were recruited from UMMHC obstetric practices and the community. Participants are 18+ years, with singleton gestation <36 >weeks, pre-pregnancy BMI 18.5-40 kg/m2, English-speaking, and with plans to deliver at UMMHC. Participants were asked “compared to the three months before you became pregnant, how is your sleep quality now?”; we combined responses of …


Aesthetically Significant: An Embodied Artistic Inquiry Exploring The Experience Of Aesthetics As An Emerging Dance/Movement Therapist, Hannah Bailey Dec 2015

Aesthetically Significant: An Embodied Artistic Inquiry Exploring The Experience Of Aesthetics As An Emerging Dance/Movement Therapist, Hannah Bailey

Creative Arts Therapies Theses

The purpose of this study was to explore my aesthetic experience as an emerging dance/movement therapist, to understand the influence my aesthetic has in my clinical work and how my aesthetic preferences are shaping me as a novice clinician. An embodied artistic inquiry was used for this self-exploration and data were collected through semi-structured journals that included both words and art. Creative synthesis was utilized for data analysis. The data collection and analysis were co-occurring for eleven weeks. At the end of each week I explored what arose in the data through movement with a board-certified dance/movement therapist (BCDMT) consultant …


A Body-Based Program Development Project To Prevent Burnout Among Mental Healthcare Professionals, Amanda J. Abeling Dec 2015

A Body-Based Program Development Project To Prevent Burnout Among Mental Healthcare Professionals, Amanda J. Abeling

Creative Arts Therapies Theses

Using the Delphi Method as a guide, a self-care program for staff members was developed out of one dance/movement therapy intern’s experiences at a suburban mental healthcare facility. Designed to increase one’s connection to self, personal observations were gathered, professionals in the field were consulted and the program was created and implemented. Themes of stress, fatigue, and burnout among the mental health care profession are discussed. Previous research on body awareness, dance/movement therapy theories, and self-care are also discussed in order to provide a framework with which to understand the development of the program. 72 pages.


Dance/Movement Therapy In-Service Model: A Collaborative Creation, Erin Arline Howe Dec 2015

Dance/Movement Therapy In-Service Model: A Collaborative Creation, Erin Arline Howe

Creative Arts Therapies Theses

The purpose of this thesis was to create a dance/movement therapy (DMT) in-service model for dance/movement therapists to effectively communicate and increase knowledge about DMT to colleagues on an interdisciplinary team. The Delphi Method was used to organize a panel of professional dance/movement therapists to collaborate and produce a cohesive in-service for other professional dance/movement therapists. Panel members offered their perspectives on the following research questions: What are effective ways to communicate the work of a dance/movement therapist to an interdisciplinary team? Which ways are ineffective in communicating the work of a dance/movement therapist to an interdisciplinary team? How do …


The Dance Of Here And Now: A Heuristic Journey Uncovering The Role Of Presence While Practicing Dance/Movement Therapy With An Elderly Population Experiencing Dementia, Kaitlynn Sinki Dec 2015

The Dance Of Here And Now: A Heuristic Journey Uncovering The Role Of Presence While Practicing Dance/Movement Therapy With An Elderly Population Experiencing Dementia, Kaitlynn Sinki

Creative Arts Therapies Theses

The goal of this heuristic research study was to further explore the concept of presence within the dance/movement therapist, and how presence could be accessed within the practice of dance/movement therapy. Specifically, how I the researcher, can efficiently utilize presence within myself as a vehicle for therapeutic change while working with an elderly population experiencing dementia. Guided by heuristic and intuitive inquiry methodologies, my personal experience of presence was observed and analyzed. Data collection took place over a three month period consisting of structured journaling, embodied movement responses, and spontaneous artmaking in relation to dance/movement therapy sessions. Findings suggested that …


Exploring Acceptance Of Using An Online Platform To Teach Parents Of Children With Autism Methods In Applied Behavior Analysis (Aba), Marwah S. Zagzoug Dec 2015

Exploring Acceptance Of Using An Online Platform To Teach Parents Of Children With Autism Methods In Applied Behavior Analysis (Aba), Marwah S. Zagzoug

Seton Hall University Dissertations and Theses (ETDs)

Background and Purpose of the Study: A diagnosis of autism can lead to lifelong struggles for parents and children. These families face profound difficulties in coping with stress while seeking out early interventions and managing imperative service needs. Parents are increasingly turning to the internet for information, advice, and even formal training. Breakthroughs in technology have made the internet more accessible and more sophisticated. The involvement of parents in applying intervention strategies to help their autistic children has long been advocated as a useful approach. Enabling parents as interventionists provides renewed confidence and reduced stress for parents as well as …


How The Rat Turned White, Kenneth J. Shapiro Dec 2015

How The Rat Turned White, Kenneth J. Shapiro

Kenneth J. Shapiro, PhD

This is the first in a three-part series on the use of animals in psychological research. In it, I describe how animals got into laboratories in the first place, and their purpose and life there. In the second, I will describe animal model research, the strategy whereby psychologists' develop nonhuman animal models to study human psychopathology. In the concluding piece, I will present a critique of this enterprise, using original data I gathered. The three articles are based on a forthcoming book, Animal Models of Human Psychology: Science, Ethics, and Policy.


A Rodent For Your Thoughts: The Animal Model Strategy In Psychology, Kenneth J. Shapiro Dec 2015

A Rodent For Your Thoughts: The Animal Model Strategy In Psychology, Kenneth J. Shapiro

Kenneth J. Shapiro, PhD

In this second of three essays, I describe how the early modern psychologists adopted the strategy of further transforming rats and other species into models of human thought, feeling, and behavior, and, particularly, of disorders of these - in effect taking "a rodent for your thoughts." In the third essay I will provide a critique and empirically-based evaluation of animal model research. Here I indicate what the model strategy in the biomedical sciences, properly understand, is intended to achieve and how, by contrast, particular models are presented to the public and funding agencies. Finally, I describe how they are utilized …


Psychology's Use Of Animals: Current Practices And Attitudes, Kenneth J. Shapiro Dec 2015

Psychology's Use Of Animals: Current Practices And Attitudes, Kenneth J. Shapiro

Kenneth J. Shapiro, PhD

In this chapter, I present a psychology primer for the uninitiated, with special emphasis on psychology's uses of animals. After sketching the scope of the field generally, I review available data on present numbers and species of animals used in psychological research, level of suffering induced and current trends. I also provide several concrete examples of psychological research involving animals. Finally, the chapter concludes with a presentation of attitudes of psychologists toward animals and these practices.


The Ingrown World Of Animal Model Research In Psychology, Kenneth J. Shapiro Dec 2015

The Ingrown World Of Animal Model Research In Psychology, Kenneth J. Shapiro

Kenneth J. Shapiro, PhD

In the previous essay, I described the proper function of models in science as heuristic, as a way of generating hypotheses about the actual object of study. Turning to animal models in psychology, I offered a general characterization of that enterprise using sham feeding, an animal model of the eating disorder called bulimia, as an example. In this final of three essays, I offer an evaluation of this animal model strategy that largely employs the tools of social science. I close with a recommendation and a prediction.


Understanding Dogs Through Kinesthetic Empathy, Social Construction, And History, Kenneth J. Shapiro Dec 2015

Understanding Dogs Through Kinesthetic Empathy, Social Construction, And History, Kenneth J. Shapiro

Kenneth J. Shapiro, PhD

The term, "come into animal presence," she takes from the title of a Denise Levertov poem. The poem, which reads, in part, "What joy when the insouciant armadillo glances at us and doesn't quicken his trotting across the track into the palm bush. What is this joy?" This joy is the possibility of our being in the presence of animals for "(t)he armadillo has some intention to pursue in the palm forest." This joy, to which I invite you here, consists in dwelling in that presence, in inhabiting that intention, that armored but guileless world of the armadillo. I will …


Criminal Law And Common Sense: An Essay On The Perils And Promise Of Neuroscience, Stephen J. Morse Dec 2015

Criminal Law And Common Sense: An Essay On The Perils And Promise Of Neuroscience, Stephen J. Morse

All Faculty Scholarship

This article is based on the author’s Barrock Lecture in Criminal Law presented at the Marquette University Law School. The central thesis is that the folk psychology that underpins criminal responsibility is correct and that our commonsense understanding of agency and responsibility and the legitimacy of criminal justice generally are not imperiled by contemporary discoveries in the various sciences, including neuroscience and genetics. These sciences will not revolutionize criminal law, at least not anytime soon, and at most they may make modest contributions to legal doctrine, practice, and policy. Until there are conceptual or scientific breakthroughs, this is my story …


Racial Attitude (Dis)Similarity And Liking In Same-Race Minority Interactions, Randi L. Garcia, Hilary B. Bergsieker, J. Nicole Shelton Dec 2015

Racial Attitude (Dis)Similarity And Liking In Same-Race Minority Interactions, Randi L. Garcia, Hilary B. Bergsieker, J. Nicole Shelton

Psychology: Faculty Publications

Two studies investigate the relationship between racial attitude (dis)similarity and interpersonal liking for racial minorities and Whites in same-race and cross-race pairs. In nationally representative and local samples, minorities report personally caring about racial issues more than Whites do (Pilot Study), which we theorize makes racial attitude divergence with ingroup members especially disruptive. Both established friendships (Study 1) and face-to-face interactions among strangers (Study 2) provided evidence for the dissimilarity-repulsion hypothesis in same-race interactions for minorities but not Whites. For minorities, disagreeing with a minority partner or friend about racial attitudes decreased their positivity toward that person. Because minorities typically …


A Clinical Trial To Validate Event-Related Potential Markers Of Alzheimer's Disease In Outpatient Settings, Marco Cecchi, Dennis K. Moore, Carl H. Sadowsky, Paul R. Solomon, P. Murali Doraiswamy, Charles D. Smith, Gregory A. Jicha, Andrew E. Budson, Steven E. Arnold, Kalford C. Fadem Dec 2015

A Clinical Trial To Validate Event-Related Potential Markers Of Alzheimer's Disease In Outpatient Settings, Marco Cecchi, Dennis K. Moore, Carl H. Sadowsky, Paul R. Solomon, P. Murali Doraiswamy, Charles D. Smith, Gregory A. Jicha, Andrew E. Budson, Steven E. Arnold, Kalford C. Fadem

Neurology Faculty Publications

INTRODUCTION: We investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD).

METHODS: A total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm.

RESULTS: Subjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task …