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Mental and Social Health

2014

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Articles 1 - 30 of 66

Full-Text Articles in Psychiatry and Psychology

Taking The Perspective That A Depressive State Reflects Inflammation: Implications For The Use Of Antidepressants, Jill Littrell Dec 2014

Taking The Perspective That A Depressive State Reflects Inflammation: Implications For The Use Of Antidepressants, Jill Littrell

jill l littrell Dr.

This paper reviews both the evidence that supports the characterization of depression as an inflammatory disorder and the different biochemical mechanisms that have been postulated for the connection between inflammation and depression. This association offers credible explanation for the short term efficacy of antidepressants, which have short term anti-inflammatory effects. Evidence for those anti-inflammatory effects is discussed. Evidence of the contrary long-term effects of antidepressants, which increase rather than decrease inflammation, is also reviewed. It is argued that this increase in inflammation would predict an increase in chronicity among depressed patients that have been treated with antidepressants drugs, which has …


Accommodating Hyperaroused Information Processing In Persons At Risk For Alcoholism, Kellianne Clark, Jaclyn Cutler Dec 2014

Accommodating Hyperaroused Information Processing In Persons At Risk For Alcoholism, Kellianne Clark, Jaclyn Cutler

Student Scholar Symposium Abstracts and Posters

In the search for the factors related to the heightened alcoholism risk in adult children of alcoholics (ACOA), it has been reported that these persons possess a high incidence of attention deficit disorders (ADD) as determined by clinical assessment instruments. However, investigations of alcoholism risk and ADD indicate that, in contrast to the hypoarousal model of ADD, the ACOA’s attention problems represent hyperarousal of attention mechanisms resulting in reduced ability to select and encode relevant information. If true, then unlike persons with ADD, clinical and cognitive assessments of ACOAs would benefit if the ACOA was provided with more time to …


Dissociation And Sexual Trauma: The Moderating Role Of Somatization, Amineh Abbas Dec 2014

Dissociation And Sexual Trauma: The Moderating Role Of Somatization, Amineh Abbas

Doctoral Dissertations

This study examined various types of trauma, with an emphasis on sexual trauma across the lifespan, in a clinical sample of male and female adult outpatients assessed for trauma, somatization, and dissociation. Two hundred forty-five adult outpatients at the University of Tennessee Psychological Clinic were administered the Dissociative Experiences Scale (DES), the Traumatic Experiences Checklist (TEC), and Symptom Checklist-90-Revised (SCL-90-R), as part of the routine intake procedure. Of those individuals, 200 patients completed the questionnaires correctly and were included in the final study sample. The experience of sexual trauma indeed accounted for additional variance in somatization scores over and above …


Is Postpartum Depression A Disease Of Modern Civilization?, Jennifer Hahn-Holbrook, Martie Haselton Dec 2014

Is Postpartum Depression A Disease Of Modern Civilization?, Jennifer Hahn-Holbrook, Martie Haselton

Psychology Faculty Articles and Research

Access to calorie-dense foods, medicine, and other comforts has made modern humans healthier than our prehistoric ancestors in many respects. However, the epidemics of obesity, diabetes, and cardiovascular disease suggest that there are also drawbacks to modern living. Here, we address the question of whether the dramatic cultural changes that have occurred over the past century have inflated rates of postpartum depression, adding postpartum depression to the list of diseases of modern civilization. We review evidence from cross-cultural, epidemiological, and experimental studies documenting associations between postpartum depression and modern patterns of early weaning, diets deficient in essential fatty acids, low …


Resilience : An Independent Psychobiological Mental Health Construct (Guest Editorial), Amresh Srivastava Nov 2014

Resilience : An Independent Psychobiological Mental Health Construct (Guest Editorial), Amresh Srivastava

Amresh Srivastava

Survival against trauma is a unique characteristic of all human beings. While a number of factors contribute in building this capacity, resilience appears to be the most important one. Interest in studying resilience arises from number of areas which are of utmost clinical significance such as such as exploring the possibility of at-risk individuals who developing a mental illness]. Resilience is a human capacity to adapt swiftly and successfully to stressful or traumatic events and revert back to a positive state. It is commonly conceptualized as the ability to thrive despite experiencing adversity


Development Of A Self-Report Measure Of Dual Diagnosis Capability For Addiction And Mental Health Programs, Kenneth E. Fletcher, Anna Kline, Tara Zandi, Gregory Seward, Sun Kim, Douglas M. Ziedonis Nov 2014

Development Of A Self-Report Measure Of Dual Diagnosis Capability For Addiction And Mental Health Programs, Kenneth E. Fletcher, Anna Kline, Tara Zandi, Gregory Seward, Sun Kim, Douglas M. Ziedonis

Douglas M. Ziedonis

The purpose of this study is to develop and test the psychometrics of a self-report version of a measure of the capacity of addiction and mental health programs to deliver dual-diagnosis treatment, that is, to provide treatment for both addiction problems and mental health problems. Traditionally these services are provided by very different service providers that did not until recently interact very well, if at all. The increasing recognition that patients who suffer from both kinds of problems – who are dually diagnosed – would benefit from integrated delivery of addiction and mental health services has led to efforts to …


Implementing The Massachusetts Child Trauma Project (Mctp) To Improve Services For Children With Complex Trauma In Child Welfare: Phase I Needs And Readiness Assessment, Charmaine B. Lo, Melodie Wenz-Gross, Jessica L. Griffin Nov 2014

Implementing The Massachusetts Child Trauma Project (Mctp) To Improve Services For Children With Complex Trauma In Child Welfare: Phase I Needs And Readiness Assessment, Charmaine B. Lo, Melodie Wenz-Gross, Jessica L. Griffin

Melodie Wenz-Gross

MCTP seeks to improve placement stability and outcomes for children with complex trauma in the care of the Massachusetts Department of Children and Families (DCF) by creating a sustainable capacity for providing evidence-based trauma interventions within provider agencies, and trauma-informed practices within DCF.


Outpatient Commitment: A Competency Based Justification, Albert J. Grudzinskas, Jeffrey L. Geller, Jonathan C. Clayfield, William H. Fisher Nov 2014

Outpatient Commitment: A Competency Based Justification, Albert J. Grudzinskas, Jeffrey L. Geller, Jonathan C. Clayfield, William H. Fisher

Jeffrey L. Geller

A recent survey of state statutes for outpatient commitment (Torrey and Kaplan, 1995) indicates that while thirty-five states and the District of Columbia have laws permitting outpatient commitment, Massachusetts is not one of them. Rather, Massachusetts uses a competency-based, substituted-decision-making model for the involuntary administration of medication in the community. To appreciate the Massachusetts model, it is important to understand how this court-ordered involuntary outpatient treatment fits into the overall scheme of outpatient commitment and how it is structured. A review of involuntary outpatient treatment (IOT) literature indicates that it is prudent to distinguish between outpatient commitment, conditional release, and …


The Family Options Project: Implementing An Innovative Intervention For Parents With Mental Illnesses And Their Families, Joanne Nicholson, Kathleen Biebel, Valerie F. Williams, Elizabeth A. Aaker, Karen Albert, Bernice Gershenson, Brenda Warren, Katherine Woolsey Nov 2014

The Family Options Project: Implementing An Innovative Intervention For Parents With Mental Illnesses And Their Families, Joanne Nicholson, Kathleen Biebel, Valerie F. Williams, Elizabeth A. Aaker, Karen Albert, Bernice Gershenson, Brenda Warren, Katherine Woolsey

Kathleen Biebel

The Family Options Project reflects a productive partnership between researchers and providers at the UMMS Center for Mental Health Services Research and Employment Options, Inc., Marlborough, MA The Family Options Intervention is an evidence-informed psychiatric rehabilitation intervention, developed and tested within the context of a community-based agency setting.


Heroin And Opiate Abuse In Ashland County, Ohio: A Public Perception Study, Oscar T. Mcknight Nov 2014

Heroin And Opiate Abuse In Ashland County, Ohio: A Public Perception Study, Oscar T. Mcknight

Oscar T McKnight Ph.D.

This research began with identifying an expert panel of professionals in Ashland County and facilitating an informational focus group on the perceived scope of heroin/opiate abuse within multiple social services, community intervention and support programs. Seven general findings emerged: 1. The overall total number of clients/cases/patients in the system has remained stable over the years; however, the proportional number of clients abusing opiates has increased. 2. That virtually every person abusing opiates enters their respective system at one point or another. 3. Only a small percent remain active with more than one system while engaged in opiate treatment. 4. Multiple …


In-Hospital Depression Predicts Early Hospital Readmission After An Acute Coronary Syndrome: Preliminary Data From Trace-Core, David Mcmanus, Jane Saczynski, Molly Waring, Milena Anatchkova, Richard Mcmanus, Robert Goldberg, Jeroan Allison, David Parish, Hamza Awad, Jerry Gurwitz, Arlene Ash, Catarina Kiefe Oct 2014

In-Hospital Depression Predicts Early Hospital Readmission After An Acute Coronary Syndrome: Preliminary Data From Trace-Core, David Mcmanus, Jane Saczynski, Molly Waring, Milena Anatchkova, Richard Mcmanus, Robert Goldberg, Jeroan Allison, David Parish, Hamza Awad, Jerry Gurwitz, Arlene Ash, Catarina Kiefe

Richard H. McManus

Background: Hospital systems, patients and providers seek to avert rehospitalizations within 30 days for patients admitted with an acute coronary syndrome (ACS). Rehospitalizations within 30 days of discharge are often considered preventable and to reflect poor in-hospital management or discharge practices. However, independent associations of psychosocial factors with early rehospitalization in patients admitted with an ACS have not been examined. Methods: A multi-racial cohort of 1,540 patients admitted with an ACS reported psychosocial factors via standardized questionnaires in an in-hospital interview. One month following discharge, patients were interviewed via phone and reported hospital readmissions. We used logistic regression models to …


Executive Functions And Social Skills In Survivors Of Pediatric Brain Tumor., Kelly Wolfe, Karin Walsh, Nina Reynolds, Francie Mitchell, Alyssa Reddy, Iris Paltin, Avi Madan-Swain Oct 2014

Executive Functions And Social Skills In Survivors Of Pediatric Brain Tumor., Kelly Wolfe, Karin Walsh, Nina Reynolds, Francie Mitchell, Alyssa Reddy, Iris Paltin, Avi Madan-Swain

Nina Reynolds

No abstract provided.


Managed Mental Health Care's Effects On Arrest And Forensic Commitment, William Fisher, Sharon-Lise Normand, Barbara Dickey, Ira Packer, Albert Grudzinskas, Hocine Azeni Oct 2014

Managed Mental Health Care's Effects On Arrest And Forensic Commitment, William Fisher, Sharon-Lise Normand, Barbara Dickey, Ira Packer, Albert Grudzinskas, Hocine Azeni

Ira K Packer

No abstract provided.


Self-Reported Lifetime Psychiatric Hospitalization Histories Of Jail Detainees With Mental Disorders: Comparison With A Non-Incarcerated National Sample, William Fisher, Ira Packer, Steven Banks, David Smith, Lorna Simon, Kristen Roy-Bujnowski Oct 2014

Self-Reported Lifetime Psychiatric Hospitalization Histories Of Jail Detainees With Mental Disorders: Comparison With A Non-Incarcerated National Sample, William Fisher, Ira Packer, Steven Banks, David Smith, Lorna Simon, Kristen Roy-Bujnowski

Ira K Packer

Lack of access to hospitalization is an often-cited risk factor for incarceration among persons with severe mental illness. This proposition is examined by comparing self-reports of lifetime psychiatric hospitalization histories of mentally ill jail inmates with data from a national sample of non-incarcerated mentally ill. Roughly 52% of mentally ill jail detainees reported at least one psychiatric hospitalization, a rate nearly three times that of the comparison group. The data call into question the notion that mentally ill jail inmates have reduced access to psychiatric inpatient treatment, without addressing the adequacy of the treatment received. Longitudinal studies are needed to …


Community Mental Health Services And The Prevalence Of Severe Mental Illness In Local Jails: Are They Related, William Fisher, Ira Packer, Lorna Simon, David Smith Oct 2014

Community Mental Health Services And The Prevalence Of Severe Mental Illness In Local Jails: Are They Related, William Fisher, Ira Packer, Lorna Simon, David Smith

Ira K Packer

The excessive prevalence of severe mental illness noted in correctional settings has sometimes been attributed to the inadequacy of community based mental health services. This study examines the prevalence of severe mental illness in two jails situated within catchment areas featuring markedly different levels of community mental health services. We use these settings to test the hypothesis that greater levels of services in a community are associated with lower prevalence of severe mental illness in the community's jail. An epidemiologic approach, using standardized field instruments, was used to estimate the prevalence of major mental illness in detainees arriving at the …


Beyond Easy Answers: Facing The Entanglements Of Violence And Psychosis, Nev Jones, Mona Shattell Phd, Rn, Faan Oct 2014

Beyond Easy Answers: Facing The Entanglements Of Violence And Psychosis, Nev Jones, Mona Shattell Phd, Rn, Faan

Mona Shattell

No abstract provided.


Percepciones De La Salud Mental En Cochabamba / Femicide In Bolivia After Perceptions Of Mental Health In Cochabamba, Phoebe House Oct 2014

Percepciones De La Salud Mental En Cochabamba / Femicide In Bolivia After Perceptions Of Mental Health In Cochabamba, Phoebe House

Independent Study Project (ISP) Collection

El propósito de este proyecto es examinar las actitudes que existen en Cochabamba, Bolivia hacia la salud mental y los trastornos mentales. Usé principalmente las entrevistas para descubrir las opiniones de profesionales de la salud mental, estudiantes de psicología y las trabajadoras de un hogar de niños que se llama la Casa de Amor para Niños, donde hice un voluntariado. Aunque los resultados de este proyecto no son generalizables a la población entera de Cochabamba, hay evidencia de opiniones generalmente negativas hacia la salud mental y los trastornos mentales. Sin embargo, también hay evidencia que estas opiniones se pueden mejorar …


Abnormal White Matter Integrity Related To Head Impact Exposure In A Season Of High School Varsity Football, Elizabeth M. Davenport, Christopher T. Whitlow, Jillian E. Urban, Mark A. Espeland, Jung Youngkyoo, Daryl A. Rosenbaum, Gerard A. Gioia, Alexander K. Powers, Joel D. Stitzel, Joseph A. Maldjian Sep 2014

Abnormal White Matter Integrity Related To Head Impact Exposure In A Season Of High School Varsity Football, Elizabeth M. Davenport, Christopher T. Whitlow, Jillian E. Urban, Mark A. Espeland, Jung Youngkyoo, Daryl A. Rosenbaum, Gerard A. Gioia, Alexander K. Powers, Joel D. Stitzel, Joseph A. Maldjian

Psychiatry and Behavioral Sciences Faculty Publications

The aim of this study was to determine whether the cumulative effects of head impacts from a season of high school football produce magnetic resonance imaging (MRI) measureable changes in the brain in the absence of clinically diagnosed concussion. Players from a local high school football team were instrumented with the Head Impact Telemetry System (HITS™) during all practices and games. All players received pre- and postseason MRI, including diffusion tensor imaging (DTI). Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) was also conducted. Total impacts and risk-weighted cumulative exposure (RWE), including linear (RWELinear), rotational (RWERotational), and …


Socio Cultural Risk Factors And Suicide Prevention, Amresh Srivastava Sep 2014

Socio Cultural Risk Factors And Suicide Prevention, Amresh Srivastava

Amresh Srivastava

Society at large, particularly in the developing countries has been undergoing rapid socio-economic changes. There are newer risk factors for mental disorders playing a crucial role in pathogenesis e.g. economic transition and social inequalities. Students suicide and farmers’s have been of particular concern.Newer challenges need befitting responses, which are seldom sufficiently available in any society. Most conspicuous barrier to identify and treat mental disorders is human resources, which is not only dismal but also unequally distributed amongst different geographical and social strata of society. Globalization has changed the agenda for mental health. It’s now demonstrated that people immigrate, they share …


The Epidemic Of Mental And Neurological Health, Mohsyn I. Malik Sep 2014

The Epidemic Of Mental And Neurological Health, Mohsyn I. Malik

Psychology Publications

This paper composes an image of modern mental and neurological health issues and looks to draw links to the current epidemic based on research and studies found online the internet and off-line. The goal is to examine what may be the underlying problem for a lot of these increases in mental health issues and neurodegenerative diseases and what are some promising clinical and sociocultural advances that may help. It explores problems such as the negative impact of the pharmaceutical giants, the increase in apathy in the work place and the general stigma towards mental disease. Through current research, the use …


Food Insecurity And Psychological Well-Being Among Women Living With Hiv/Aids On Antiretroviral Therapy In The Alabama Black Belt, Andrew A. Zekeri, Youssouf Diabate Sep 2014

Food Insecurity And Psychological Well-Being Among Women Living With Hiv/Aids On Antiretroviral Therapy In The Alabama Black Belt, Andrew A. Zekeri, Youssouf Diabate

Professional Agricultural Workers Journal

The objective of this research was to estimate the prevalence of food insecurity and determine if food insecurity is associated with psychological well-being among women living with HIV/AIDS. Survey data were collected from 268 women living with HIV/AIDS attending two clinics that provide medical and social support services to HIV-positive patients who live in 23 counties in Southeast Alabama. The results indicated that, using USDA food security scale, 54% of the women were food insecure. Multiple regression analysis results indicated that income, depressive symptoms, race, and participation in SNAP were significant predictors of food insecurity; employment and education were not …


Psychiatry And Efforts To Build Community In Iraq., Amir A Afkhami Sep 2014

Psychiatry And Efforts To Build Community In Iraq., Amir A Afkhami

Psychiatry and Behavioral Sciences Faculty Publications

No abstract provided.


An Introduction To Drugs And The Neuroscience Of Behavior, Adam Prus Aug 2014

An Introduction To Drugs And The Neuroscience Of Behavior, Adam Prus

Adam J Prus

This up-to-date new text provides an introductory overview of the nervous system actions and behavioral effects of the major classes of psychoactive drugs. Appropriate for undergraduate students who have an introductory level background in psychology or other areas within the social sciences, AN INTRODUCTION TO DRUGS AND THE NEUROSCIENCE OF BEHAVIOR illustrates concepts and highlights research techniques. The book's most important feature is its pedagogical elements, which are not found in other psychopharmacology texts, but are particularly important for making this specialized topic approachable for undergraduates. Charts and diagrams illustrate basic concepts and processes important for understanding the actions and …


Honorable Mention: 27th Annual No Big Heads Exhibition, Adam Prus Aug 2014

Honorable Mention: 27th Annual No Big Heads Exhibition, Adam Prus

Adam J Prus

This up-to-date new text provides an introductory overview of the nervous system actions and behavioral effects of the major classes of psychoactive drugs. Appropriate for undergraduate students who have an introductory level background in psychology or other areas within the social sciences, AN INTRODUCTION TO DRUGS AND THE NEUROSCIENCE OF BEHAVIOR illustrates concepts and highlights research techniques. The book's most important feature is its pedagogical elements, which are not found in other psychopharmacology texts, but are particularly important for making this specialized topic approachable for undergraduates. Charts and diagrams illustrate basic concepts and processes important for understanding the actions and …


Cluster B Personality Disorders Separated By Gender Expectations, Brianna Kloss Aug 2014

Cluster B Personality Disorders Separated By Gender Expectations, Brianna Kloss

Journal of Undergraduate Research at Minnesota State University, Mankato

Criticisms of the Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; DSM-IV-TR; American Psychiatric Association [APA], 2000), the most widely recognized system for classification of psychological disorders in the U.S., including gender discriminating disorders and diagnoses, have existed for all editions of the DSM. Arguably, gender construction has a profound influence on the standards and evaluation of normal and abnormal behaviors. Concern for the presence of gender bias of personality disorders has been raised within the DSM, in part, by the frequent diagnoses made according to gender stereotypes. The DSM-IV-TR characterizes personality disorders as marked distress and …


Tapping To A Slow Tempo In The Presence Of Simple And Complex Musical Meters Reveals Experience-Specific Biases For Processing Music, Sangeeta Ullal-Gupta, Erin E. Hannon, Joel S. Snyder Jul 2014

Tapping To A Slow Tempo In The Presence Of Simple And Complex Musical Meters Reveals Experience-Specific Biases For Processing Music, Sangeeta Ullal-Gupta, Erin E. Hannon, Joel S. Snyder

Psychology Faculty Research

Musical meters vary considerably across cultures, yet relatively little is known about how culture-specific experience influences metrical processing. In Experiment 1, we compared American and Indian listeners' synchronous tapping to slow sequences. Inter-tone intervals contained silence or to-be-ignored rhythms that were designed to induce a simple meter (familiar to Americans and Indians) or a complex meter (familiar only to Indians). A subset of trials contained an abrupt switch from one rhythm to another to assess the disruptive effects of contradicting the initially implied meter. In the unfilled condition, both groups tapped earlier than the target and showed large tap-tone asynchronies …


Relaxation Training And Opioid Inhibition Of Blood Pressure Response To Stress, James Mccubbin, John Wilson, Stephen Bruehl, Paloma Ibarra, Charles Carlson, Jane Norton, George Colclough Jul 2014

Relaxation Training And Opioid Inhibition Of Blood Pressure Response To Stress, James Mccubbin, John Wilson, Stephen Bruehl, Paloma Ibarra, Charles Carlson, Jane Norton, George Colclough

James A. McCubbin

The present study was designed to determine the role of endogenous opioid mechanisms in the circulatory effects of relaxation training. Opioid mechanisms were assessed by examination of the effects of opioid receptor blockade with naltrexone on acute cardiovascular reactivity to laboratory stress before and after relaxation training. 32 young men with mildly elevated casual arterial pressure were recruited for placebo-controlled naltrexone stress tests and relaxation training. The results indicated that relaxation training significantly reduced the diastolic pressure response to mental arithmetic stress. Opioid receptor blockade with naltrexone antagonized the effects of relaxation training. These findings suggest that some of the …


Psychological Coping With Acute Pain: An Examination Of The Role Of Endogenous Opioid Mechanisms, Stephen Bruehl, Charles Carlson, John Wilson, Jane Norton, George Colclough, Marianne Brady, Jeffrey Sherman, James Mccubbin Jul 2014

Psychological Coping With Acute Pain: An Examination Of The Role Of Endogenous Opioid Mechanisms, Stephen Bruehl, Charles Carlson, John Wilson, Jane Norton, George Colclough, Marianne Brady, Jeffrey Sherman, James Mccubbin

James A. McCubbin

This study examined the relationship among endogenous opioids, Monitoring and Blunting coping styles, and acute pain responses. Fifty-eight male subjects underwent a 1-min pressure pain stimulus during two laboratory sessions. Subjects experienced this pain stimulus once under endogenous opioid blockade with naltrexone and once in a placebo condition. Blunting was found to be negatively correlated with pain ratings, but this relationship was significantly more prominent under opioid blockade. Results for coping behaviors subjects used to manage the experimental pain were generally consistent with the Blunting results, indicating that cognitive coping was related more strongly to decreased pain ratings and cardiovascular …


The Psychobiology Of Hostility: Possible Endogenous Opioid Mechanisms, Stephen Bruehl, James Mccubbin, Charles Carlson, John Wilson, Jane Norton, George Colclough, Marianne Brady, Jeffrey Sherman Jul 2014

The Psychobiology Of Hostility: Possible Endogenous Opioid Mechanisms, Stephen Bruehl, James Mccubbin, Charles Carlson, John Wilson, Jane Norton, George Colclough, Marianne Brady, Jeffrey Sherman

James A. McCubbin

This study examined the role of endogenous opioids in the relation between hostility and cardiovascular stress responsiveness. Forty-six mencompleted the Cook-Medley Hostility Scale, and experienced a laboratory pain stressor once under opioid blockade and once under placebo. Hostility scores were significantly related to the magnitude of change in cardiovascular reactivity/recovery resulting from opioid blockade. Low scorers on the Cynicism subscalc displayed increases in heart rate (HR) reactivity under blockade relative to placebo, with reactivity decreases noted in high scorers. Low Hostile Affect scores were similarly associated with impaired diastolic blood pressure recovery under opioid blockade. HR recovery results were somewhat …


An Unusual Reaction To Opioid Blockade With Naltrexone In A Case Of Posttraumatic Stress Disorder, Paloma Ibarra, Stephen P. Bruehl, James A. Mccubbin, Charles R. Carlson, John F. Wilson, Jane A. Norton, Thomas B. Montgomery Jul 2014

An Unusual Reaction To Opioid Blockade With Naltrexone In A Case Of Posttraumatic Stress Disorder, Paloma Ibarra, Stephen P. Bruehl, James A. Mccubbin, Charles R. Carlson, John F. Wilson, Jane A. Norton, Thomas B. Montgomery

James A. McCubbin

An unusual behavioral and cardiovascular reaction was observed during opioid blockade with naltrexone in a 32-year-old male who met DSM III-R criteria for post-traumatic stress disorder (PTSD). As part of an ongoing placebo-controlled investigation of the effects of naltrexone on laboratory and ambulatory blood pressure reactivity, this participant reported experiencing feelings of rage, explosive behavior, and other unpleasant symptoms. When compared to all other subjects (N=24), this individual showed significantly greater effects of naltrexone on blood pressure reactivity during the laboratory stressor. His ambulatory blood pressures, when compared to placebo, were significantly increased during the 24-hr period following naltrexone. The …