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Full-Text Articles in Psychiatry and Psychology
Data-Driven Neuroanatomical Subtypes In Various Stages Of Schizophrenia: Linking Cortical Thickness, Glutamate, And Language Functioning, Liangbing Liang
Data-Driven Neuroanatomical Subtypes In Various Stages Of Schizophrenia: Linking Cortical Thickness, Glutamate, And Language Functioning, Liangbing Liang
Electronic Thesis and Dissertation Repository
The considerable variation in the spatial distribution of cortical thickness changes has been used to parse heterogeneity in schizophrenia. We aimed to recover a ‘cortical impoverishment’ subgroup with widespread cortical thinning. We applied hierarchical cluster analysis to cortical thickness data of three datasets in different stages of psychosis and studied the cognitive, functional, neurochemical, language and symptom profiles of the observed subgroups. Our consensus-based clustering procedure consistently produced a subgroup characterized by significantly lower cortical thickness. This ‘cortical impoverishment’ subgroup was associated with a higher symptom burden in a clinically stable sample and higher glutamate levels with language impairments in …
Inviting Hallucinatory Percepts During Speech-Listening To Detect Cognitive Changes In Early Psychosis, Ana-Bianca Popa
Inviting Hallucinatory Percepts During Speech-Listening To Detect Cognitive Changes In Early Psychosis, Ana-Bianca Popa
Electronic Thesis and Dissertation Repository
Treatment outcomes for people with schizophrenia are more favourable if treatment starts early in the course of the disorder. Current detection methods lack specificity and do not make use of cognitive markers. We presented individuals experiencing a first episode of psychosis (FEP) and matched control participants with acoustically degraded meaningful and matched nonsense sentences to examine the degree to which people reported words that were not actually presented. Intrusion errors were counted when reported words were unrelated to words in the original sentence. Intelligibility (measured as words reported correctly) did not differ between groups but intrusion errors were more frequent …