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Other Medicine and Health Sciences Commons™
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Full-Text Articles in Other Medicine and Health Sciences
Sperm Dna Methylation Mediates The Association Of Male Age On Reproductive Outcomes Among Couples Undergoing Infertility Treatment, Oladele A. Oluwayiose, Haotian Wu, Hachem Saddiki, Brian W. Whitcomb, Laura B. Balzer, Nicole Brandon, Alexander Suvorov, Rahil Tayyab, Cynthia K. Sites, Lisa Hill, Chelsea Marcho, J. Richard Pilsner
Sperm Dna Methylation Mediates The Association Of Male Age On Reproductive Outcomes Among Couples Undergoing Infertility Treatment, Oladele A. Oluwayiose, Haotian Wu, Hachem Saddiki, Brian W. Whitcomb, Laura B. Balzer, Nicole Brandon, Alexander Suvorov, Rahil Tayyab, Cynthia K. Sites, Lisa Hill, Chelsea Marcho, J. Richard Pilsner
Environmental Health Sciences Faculty Publication Series
Parental age at time of offspring conception is increasing in developed countries. Advanced male age is associated with decreased reproductive success and increased risk of adverse neurodevelopmental outcomes in offspring. Mechanisms for these male age effects remain unclear, but changes in sperm DNA methylation over time is one potential explanation. We assessed genome-wide methylation of sperm DNA from 47 semen samples collected from male participants of couples seeking infertility treatment. We report that higher male age was associated with lower likelihood of fertilization and live birth, and poor embryo development (p < 0.05). Furthermore, our multivariable linear models showed male age was associated with alterations in sperm methylation at 1698 CpGs and 1146 regions (q < 0.05), which were associated with > 750 genes enriched in embryonic development, behavior and neurodevelopment …
Developmental Exposures To Perfluorooctanesulfonic Acid (Pfos) Impact Embryonic Nutrition, Pancreatic Morphology, And Adiposity In The Zebrafish, Danio Rerio, Karilyn E. Sant, Kate Annunziato, Sarah Conlin, Gregory Teicher, Phoebe Chen, Olivia Venezia, Gerald B. Downes, Yeonhwa Park, Alicia R. Timme-Laragy
Developmental Exposures To Perfluorooctanesulfonic Acid (Pfos) Impact Embryonic Nutrition, Pancreatic Morphology, And Adiposity In The Zebrafish, Danio Rerio, Karilyn E. Sant, Kate Annunziato, Sarah Conlin, Gregory Teicher, Phoebe Chen, Olivia Venezia, Gerald B. Downes, Yeonhwa Park, Alicia R. Timme-Laragy
Environmental Health Sciences Faculty Publication Series
Perfluorooctanesulfonic acid (PFOS) is a persistent environmental contaminant previously found in consumer surfactants and industrial fire-fighting foams. PFOS has been widely implicated in metabolic dysfunction across the lifespan, including diabetes and obesity. However, the contributions of the embryonic environment to metabolic disease remain uncharacterized. This study seeks to identify perturbations in embryonic metabolism, pancreas development, and adiposity due to developmental and subchronic PFOS exposures and their persistence into later larval and juvenile periods. Zebrafish embryos were exposed to 16 or 32 μM PFOS developmentally (1–5 days post fertilization; dpf) or subchronically (1–15 dpf). Embryonic fatty acid and macronutrient concentrations and …
Space-Time Characterization Of Community Noise And Sound Sources In Accra, Ghana, Sierra N. Clark, Abosede S. Alli, Ricky Nathvani, Allison Hughes, Majid Ezzati, Michael Brauer, Mireille B. Toledano, Jill Baumgartner, James E. Bennett, James Nimo
Space-Time Characterization Of Community Noise And Sound Sources In Accra, Ghana, Sierra N. Clark, Abosede S. Alli, Ricky Nathvani, Allison Hughes, Majid Ezzati, Michael Brauer, Mireille B. Toledano, Jill Baumgartner, James E. Bennett, James Nimo
Environmental Health Sciences Faculty Publication Series
Urban noise pollution is an emerging public health concern in growing cities in sub-Saharan Africa (SSA), but the sound environment in SSA cities is understudied. We leveraged a large-scale measurement campaign to characterize the spatial and temporal patterns of measured sound levels and sound sources in Accra, Ghana. We measured sound levels and recorded audio clips at 146 representative locations, involving 7-days (136 locations) and 1-year measurements between 2019 and 2020. We calculated metrics of noise levels and intermittency and analyzed audio recordings using a pre-trained neural network to identify sources. Commercial, business, and industrial areas and areas near major …
Chemical Exposures Affect Innate Immune Response To Sars-Cov-2, Olatunbosun Arowolo, Leonid Pobezinsky, Alexander Suvorov
Chemical Exposures Affect Innate Immune Response To Sars-Cov-2, Olatunbosun Arowolo, Leonid Pobezinsky, Alexander Suvorov
Environmental Health Sciences Faculty Publication Series
Severe outcomes of COVID-19 are associated with pathological response of the immune system to the SARS-CoV-2 infection. Emerging evidence suggests that an interaction may exist between COVID-19 pathogenesis and a broad range of xenobiotics, resulting in significant increases in death rates in highly exposed populations. Therefore, a better understanding of the molecular basis of the interaction between SARS-CoV-2 infection and chemical exposures may open opportunities for better preventive and therapeutic interventions. We attempted to gain mechanistic knowledge on the interaction between SARS-CoV-2 infection and chemical exposures using an in silico approach, where we identified genes and molecular pathways affected by …