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Full-Text Articles in Nanotechnology

Fabrication Of Nanofiber Scaffolds With Gradations In Fiber Organization And Their Potential Applications, Jingwei Xie, Bing Ma, Praveesuda Michael, Franklin Shuler Jun 2015

Fabrication Of Nanofiber Scaffolds With Gradations In Fiber Organization And Their Potential Applications, Jingwei Xie, Bing Ma, Praveesuda Michael, Franklin Shuler

Praveesuda Lorwattanapongsa Michael

A new and simple method for fabrication of nanofiber scaffolds with gradations in fiber organization is reported. The nanofiber organization, achieved by deposition of random fibers on the uniaxially-aligned nanofiber mat in a gradient manner, directed morphological changes of applied adipose-derived stem cells. These morphological changes and resultant biochemical changes can help mimic the structural orientation of complex biomechanical structures like the collagen fiber structure at the tendon-to-bone insertion site. In addition, chemical gradients can be established through nanoencapsulation in this novel scaffold allowing for enhanced biomedical applications.


Fabrication Of Nanofiber Scaffolds With Gradations In Fiber Organization And Their Potential Applications, Jingwei Xie, Bing Ma, Praveesuda Michael, Franklin Shuler Jun 2015

Fabrication Of Nanofiber Scaffolds With Gradations In Fiber Organization And Their Potential Applications, Jingwei Xie, Bing Ma, Praveesuda Michael, Franklin Shuler

Jingwei Xie

A new and simple method for fabrication of nanofiber scaffolds with gradations in fiber organization is reported. The nanofiber organization, achieved by deposition of random fibers on the uniaxially-aligned nanofiber mat in a gradient manner, directed morphological changes of applied adipose-derived stem cells. These morphological changes and resultant biochemical changes can help mimic the structural orientation of complex biomechanical structures like the collagen fiber structure at the tendon-to-bone insertion site. In addition, chemical gradients can be established through nanoencapsulation in this novel scaffold allowing for enhanced biomedical applications.


Fabrication Of Nanofiber Scaffolds With Gradations In Fiber Organization And Their Potential Applications, Jingwei Xie, Bing Ma, Praveesuda Michael, Franklin Shuler Jun 2015

Fabrication Of Nanofiber Scaffolds With Gradations In Fiber Organization And Their Potential Applications, Jingwei Xie, Bing Ma, Praveesuda Michael, Franklin Shuler

Bing Ma

A new and simple method for fabrication of nanofiber scaffolds with gradations in fiber organization is reported. The nanofiber organization, achieved by deposition of random fibers on the uniaxially-aligned nanofiber mat in a gradient manner, directed morphological changes of applied adipose-derived stem cells. These morphological changes and resultant biochemical changes can help mimic the structural orientation of complex biomechanical structures like the collagen fiber structure at the tendon-to-bone insertion site. In addition, chemical gradients can be established through nanoencapsulation in this novel scaffold allowing for enhanced biomedical applications.