Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Arrayed sensor (1)
- Cancer therapy (1)
- Chemical stimulation (1)
- Curcumin (1)
- GBM stem cells (1)
-
- Glioblastoma (GBM) (1)
- Graphene nanoplatelets (1)
- Liquid flow control (1)
- Local chemical delivery (1)
- Low voltage actuation (1)
- Macroporous silicon membrane (1)
- NK cells (1)
- Oncoimmunotherapy (1)
- Photothermal (1)
- Polypyrrole (1)
- Thermo responsive hydrogel (1)
- Tumor-associated microglia/macrophages (TAM) (1)
- Valveless micropump (1)
Articles 1 - 2 of 2
Full-Text Articles in Nanotechnology
Development Of Light Actuated Chemical Delivery Platform On A 2-D Array Of Micropore Structure, Hojjat Rostami Azmand, Hojjat Rostami Azmand
Development Of Light Actuated Chemical Delivery Platform On A 2-D Array Of Micropore Structure, Hojjat Rostami Azmand, Hojjat Rostami Azmand
Dissertations and Theses
Localized chemical delivery plays an essential role in the fundamental information transfers within biological systems. Thus, the ability to mimic the natural chemical signal modulation would provide significant contributions to understand the functional signaling pathway of biological cells and develop new prosthetic devices for neurological disorders. In this paper, we demonstrate a light-controlled hydrogel platform that can be used for localized chemical delivery in a high spatial resolution. By utilizing the photothermal behavior of graphene-hydrogel composites confined within micron-sized fluidic channels, patterned light illumination creates the parallel and independent actuation of chemical release in a group of fluidic ports. The …
Strategies Involving The Food-Derived Agent Curcumin To Eliminate Brain Cancer, Sumit Mukherjee
Strategies Involving The Food-Derived Agent Curcumin To Eliminate Brain Cancer, Sumit Mukherjee
Dissertations, Theses, and Capstone Projects
Glioblastoma (GBM) is one of the most deadly forms of cancer with a mean 5-year survival rate of ≤5%. We have used the non-invasive strategy of long-term intranasal (IN) delivery of a glioblastoma-directed adduct of curcumin (CC), CC-CD68Ab, into the brain of murine GBM cell line GL261-implanted mice to study the therapeutic effect of CC on GBM remission. The treatment caused GBM tumor remission in 50% of GL261-implanted GBM mice. A similar rescue rate (60%) was also achieved through long-term intraperitoneal (i.p) infusion of a highly bioavailable phosphotidylcholine (PC)-encapsulated formulation of CC, Curcumin Phytosome Meriva (CCP), into the GL261-implanted GBM …