Mental and Social Health Commons^™

The Ecological Genomic Basis Of Salinity Adaptation In Tunisian Medicago Truncatula, Maren L. Friesen, Eric J.B. Von Wettberg, Mounawer Badri, Ken S. Moriuchi, Fathi Barhoumi, Peter L. Chang, Sonia Cuellar-Ortiz, Matilde A. Cordeiro, Wendy T. Vu, Soumaya Arraouadi, Naceur Djébali, Kais Zribi, Yazid Badri, Stephanie S. Porter, Mohammed Elarbi Aouani, Douglas R. Cook, Sharon Y. Strauss, Sergey V. Nuzhdin

College of Agriculture and Life Sciences Faculty Publications

Background: As our world becomes warmer, agriculture is increasingly impacted by rising soil salinity and understanding plant adaptation to salt stress can help enable effective crop breeding. Salt tolerance is a complex plant phenotype and we know little about the pathways utilized by naturally tolerant plants. Legumes are important species in agricultural and natural ecosystems, since they engage in symbiotic nitrogen-fixation, but are especially vulnerable to salinity stress. Results: Our studies of the model legume Medicago truncatula in field and greenhouse settings demonstrate that Tunisian populations are locally adapted to saline soils at the metapopulation level and that saline origin …

A More Efficient Nonparametric Test Of Symmetry Based On Overlapping Coefficient, Hani M. Samawi, Robert L. Vogel

Biostatistics Faculty Publications

In this paper we provide a more efficient nonparametric test of symmetry based on the empirical overlap coefficient using kernel density estimation applied to an extreme order statistics, namely extreme ranked set sampling. Our simulation investigation reveals that our proposed test of symmetry is at least as powerful as currently available tests of symmetry. Intensive simulation is conducted to examine the power of the proposed test. An illustration is provided using cardiac output and body weight of neonates in a neonatal intensive care unit.

Overview Of Inference About Roc Curve In Medical Diagnosis, Jingjing Yin

Biostatistics Faculty Publications

Medical diagnosis aims to identify diseased individuals through the evaluation of the measurements of some biomarkers by performing a diagnostic test based on some biomarker measurements. Biomarkers are measured on either discrete or continuous scale and continuous biomarkers are utilized more often in medical practice. This article introduces the most popular tool for evaluating continuous biomarkers: the Receiver Operating Characteristic (ROC) curve.

Lung Flute Improves Symptoms And Health Status In Copd With Chronic Bronchitis: A 26 Week Randomized Controlled Trial, Sanjay Sethi, Jingjing Yin, Pamela K. Anderson

Biostatistics Faculty Publications

Background: Chronic obstructive pulmonary disease (COPD) is characterized by mucus hypersecretion that contributes to disease related morbidity and is associated with increased mortality. The Lung Flute® is a new respiratory device that produces a low frequency acoustic wave with moderately vigorous exhalation to increase mucus clearance. We hypothesized that the Lung Flute, used on a twice daily basis will provide clinical benefit to patients with COPD with chronic bronchitis.

Methods: We performed a 26 week randomized, non-intervention controlled, single center, open label trial in 69 patients with COPD and Chronic Bronchitis. The primary endpoint was change in respiratory symptoms measured …

Mental Health Awareness Building Via Android Application, James Faraday, Joshua Martin

Journal of Undergraduate Research at Minnesota State University, Mankato

The goal of this project was to create a tool that provides students at Minnesota State University, Mankato with mental health information through a freely available smartphone application (App). Our approach used a software engineering design process that focused on who our customers are, what resources are available, and how we can best connect the two to improve student lives. We identified the stakeholders involved and worked with campus mental health professionals to help shape our App. While there is a broad range of mental health topics, we have focused on materials related to depression. The first process of the …

Exploring Germplasm Diversity To Understand The Domestication Process In Cicer Spp. Using Snp And Dart Markers, Manish Roorkiwal, Eric J. Von Wettberg, Hari D. Upadhyaya, Emily Warschefsky, Abhishek Rathore, Rajeev K. Varshney

College of Agriculture and Life Sciences Faculty Publications

To estimate genetic diversity within and between 10 interfertile Cicer species (94 genotypes) from the primary, secondary and tertiary gene pool, we analysed 5,257 DArT markers and 651 KASPar SNP markers. Based on successful allele calling in the tertiary gene pool, 2,763 DArT and 624 SNP markers that are polymorphic between genotypes from the gene pools were analyzed further. STRUCTURE analyses were consistent with 3 cultivated populations, representing kabuli, desi and pea-shaped seed types, with substantial admixture among these groups, while two wild populations were observed using DArT markers. AMOVA was used to partition variance among hierarchical sets of landraces …

From Drug Use To Dependence: A Multiparametric Approach, Olga A. Vsevolozhskaya, James C. Anthony

Olga A. Vsevolozhskaya

One of the hallmarks of a drug dependence (DD) process is an escalation in rate of drug self-administration (DSA). We seek to extend current biostatistical approaches for epidemiological research on drug dependence processes via an investigation of a four-parameter dose-effect curve (DEC).

Design, Synthesis And Biological Evaluation Of Novel Compounds With Cns-Activity Targeting Cannabinoid And Biogenic Amine Receptors, Alexander M. Sherwood

University of New Orleans Theses and Dissertations

This work seeks to contribute to the discipline of neuropharmacology by way of structure activity relationship from the standpoint of an organic chemist. More specifically, we sought to develop robust synthetic methodology able to efficiently produce an array of compounds for the purpose of systematic evaluation of their interaction with specific sights within the central nervous system (CNS) in order to better understand the mind and to develop drugs that may have beneficial effects on neurological function.

The focus of these studies has been toward the development of novel molecules, using a structure-activity relationship approach, that exhibit binding affinity at …

New Perspectives In Ecosystem Services Science As Instruments To Understand Environmental Securities, Ferdinando Villa, Brian Voigt, Jon D. Erickson

Rubenstein School of Environment and Natural Resources Faculty Publications

As societal demand for food, water and other life-sustaining resources grows, the science of ecosystem services (ES) is seen as a promising tool to improve our understanding, and ultimately the management, of increasingly uncertain supplies of critical goods provided or supported by natural ecosystems. This promise, however, is tempered by a relatively primitive understanding of the complex systems supporting ES, which as a result are often quantified as static resources rather than as the dynamic expression of human-natural systems. This article attempts to pinpoint the minimum level of detail that ES science needs to achieve in order to usefully inform …

Confidence Interval Estimation In R-Das: State-Level Estimates For Extra-Medical Use Of Prescription Pain Relievers, Olga A. Vsevolozhskaya, James C. Anthony

Olga A. Vsevolozhskaya

The specific methodological aims of our research are: 1) to clarify statistical inference procedures used by R-DAS to produce confidence interval estimates; 2) to review a simple solution to some of the research questions not currently addressed by R-DAS (i.e., with respect to tests of significance); and 3) to describe how in certain situations the percentages and the corresponding standard errors, which are suppressed from the R-DAS output due to the confidentiality concerns can be estimated “by hand”.

A Methodology For Adaptable And Robust Ecosystem Services Assessment, Ferdinando Villa, Kenneth J. Bagstad, Brian Voigt, Gary W. Johnson, Rosimeiry Portela, Miroslav Honzák, David Batker

Rubenstein School of Environment and Natural Resources Faculty Publications

Ecosystem Services (ES) are an established conceptual framework for attributing value to the benefits that nature provides to humans. As the promise of robust ES-driven management is put to the test, shortcomings in our ability to accurately measure, map, and value ES have surfaced. On the research side, mainstream methods for ES assessment still fall short of addressing the complex, multi-scale biophysical and socioeconomic dynamics inherent in ES provision, flow, and use. On the practitioner side, application of methods remains onerous due to data and model parameterization requirements. Further, it is increasingly clear that the dominant "one model fits all" …

A Novel Three Serum Phospholipid Panel Differentiates Normal Individuals From Those With Prostate Cancer, Nima Patel, Robert L. Vogel, Kumar Chandra-Kuntal, Wayne Glasgow, Uddhav Kelavkar

Biostatistics Faculty Publications

Background: The results of prostate specific antigen (PSA) and digital rectal examination (DRE) screenings lead to both under and over treatment of prostate cancer (PCa). As such, there is an urgent need for the identification and evaluation of new markers for early diagnosis and disease prognosis. Studies have shown a link between PCa, lipids and lipid metabolism. Therefore, the aim of this study was to examine the concentrations and distribution of serum lipids in patients with PCa as compared with serum from controls.

Method: Using Electrospray ionization mass spectrometry (ESI-MS/MS) lipid profiling, we analyzed serum phospholipids from age-matched subjects who …

A Phylogenetic Model For Understanding The Effect Of Gene Duplication On Cancer Progression, Qin Ma, Jaxk H. Reeves, David A. Liberles, Lili Yu, Zheng Chang, Jing Zhao, Juan Cui, Ying Xu, Liang Liu

Biostatistics Faculty Publications

As biotechnology advances rapidly, a tremendous amount of cancer genetic data has become available, providing an unprecedented opportunity for understanding the genetic mechanisms of cancer. To understand the effects of duplications and deletions on cancer progression, two genomes (normal and tumor) were sequenced from each of five stomach cancer patients in different stages (I, II, III and IV). We developed a phylogenetic model for analyzing stomach cancer data. The model assumes that duplication and deletion occur in accordance with a continuous time Markov Chain along the branches of a phylogenetic tree attached with five extended branches leading to the tumor …

Genetic Diversity And Demographic History Of Cajanus Spp. Illustrated From Genome-Wide Snps, Rachit K. Saxena, Eric Von Wettberg, Hari D. Upadhyaya, Vanessa Sanchez, Serah Songok, Kulbhushan Saxena, Paul Kimurto, Rajeev K. Varshney

College of Agriculture and Life Sciences Faculty Publications

Understanding genetic structure of Cajanus spp. is essential for achieving genetic improvement by quantitative trait loci (QTL) mapping or association studies and use of selected markers through genomic assisted breeding and genomic selection. After developing a comprehensive set of 1,616 single nucleotide polymorphism (SNPs) and their conversion into cost effective KASPar assays for pigeonpea (Cajanus cajan), we studied levels of genetic variability both within and between diverse set of Cajanus lines including 56 breeding lines, 21 landraces and 107 accessions from 18 wild species. These results revealed a high frequency of polymorphic SNPs and relatively high level of cross-species transferability. …

Is Hyperbaric Oxygen Therapy An Effective Treatment For Autism? A Review, Daniel Dunleavy, Bruce A. Thyer

Journal of Adolescent and Family Health

Objectives: We review outcome studies regarding the effectiveness of hyperbaric oxygen therapy (HBOT) for Autism Spectrum Disorders (ASD). Method: Studies were identified through electronic bibliographic databases and manual searches of article reference lists. Results: A total of 8 studies met eligibility criteria, consisting of three randomized controlled trials (RCTs), one quasi-experimental study involving a comparison group, two pre-experimental one-group pretest–posttest studies, and two single-system designs. Studies reviewed did not offer credible evidence to suggest that HBOT is an effective treatment for autism. Conclusion: It is premature to call HBOT an effective treatment for Autism and ASD. Individuals clinically treated with …

Predictors And Moderators Of Outcomes Of Hiv/Std Sex Risk Reduction Interventions In Substance Abuse Treatment Programs: A Pooled Analysis Of Two Randomized Controlled Trials, Paul Crits-Christoph, Robert Gallop, Jaclyn S. Sadicario, Hannah M. Markell, Donald A. Calsyn, Wan Tang, Hua He, Xin Tu, George Woody

Mathematics Faculty Publications

No abstract provided.

Relationship Between Altitude And Lithium In Groundwater In The United States Of America: Results Of A 1992–2003 Study, Rebekah S. Huber, Namkug Kim, Carl E. Renshaw, Perry F. Renshaw, Douglas Kondo

Dartmouth Scholarship

Therapeutic dosages of lithium are known to reduce suicide rates, which has led to investigations of confounding environmental risk factors for suicide such as lithium in groundwater. It has been speculated that this might play a role in the potential relationship between suicide and altitude. A recent study in Austria involving geospatial analysis of lithium in groundwater and suicide found lower levels of lithium at higher altitudes. Since there is no reason to suspect this correlation is universal given variation in geology, the current study set out to investigate the relationship between altitude and lithium in groundwater in the United …

The Forest Has A Story: Cultural Ecosystem Services In Kona, Hawai‘I, Rachelle K. Gould, Nicole M. Ardoin, Ulalia Woodside, Terre Satterfield, Neil Hannahs, Gretchen C. Daily

Rubenstein School of Environment and Natural Resources Faculty Publications

Understanding cultural dimensions of human/environment relationships is now widely seen as key to effective management, yet characterizing these dimensions remains a challenge. We report on an approach for considering the nonmaterial values associated with ecosystems, i.e., cultural ecosystem services. We applied the approach in Kona, Hawai‘i, using 30 semistructured interviews and 205 in-person surveys, striving to balance pragmatism and depth. We found spirituality, heritage, and identity-related values to be particularly salient, with expression of some of these values varying among respondents by ethnicity and duration of residence in Hawai‘i. Although people of various backgrounds reported strong spirituality and heritage-related values, …

Whales As Marine Ecosystem Engineers, Joe Roman, James A. Estes, Lyne Morissette, Craig Smith, Daniel Costa, James Mccarthy, J. B. Nation, Stephen Nicol, Andrew Pershing, Victor Smetacek

Rubenstein School of Environment and Natural Resources Faculty Publications

Baleen and sperm whales, known collectively as the great whales, include the largest animals in the history of life on Earth. With high metabolic demands and large populations, whales probably had a strong influence on marine ecosystems before the advent of industrial whaling: as consumers of fish and invertebrates; as prey to other large-bodied predators; as reservoirs of and vertical and horizontal vectors for nutrients; and as detrital sources of energy and habitat in the deep sea. The decline in great whale numbers, estimated to be at least 66% and perhaps as high as 90%, has likely altered the structure …

Impacts Of Projected Climate Change Over The Lake Champlain Basin In Vermont, Justin Guilbert, Brian Beckage, Jonathan M. Winter, Radley M. Horton, Timothy Perkins, Arne Bomblies

College of Agriculture and Life Sciences Faculty Publications

The Lake Champlain basin is a critical ecological and socioeconomic resource of the northeastern United States and southern Quebec, Canada. While general circulation models (GCMs) provide an overview of climate change in the region, they lack the spatial and temporal resolution necessary to fully anticipate the effects of rising global temperatures associated with increasing greenhouse gas concentrations. Observed trends in precipitation and temperature were assessed across the Lake Champlain basin to bridge the gap between global climate change and local impacts. Future shifts in precipitation and temperature were evaluated as well as derived indices, including maple syrup production, days above …

Shade Coffee: Update On A Disappearing Refuge For Biodiversity, Shalene Jha, Christopher M. Bacon, Stacy M. Philpott, V. Ernesto Méndez, Peter Läderach, Robert A. Rice

College of Agriculture and Life Sciences Faculty Publications

In the past three decades, coffee cultivation has gained widespread attention for its crucial role in supporting local and global biodiversity. In this synthetic Overview, we present newly gathered data that summarize how global patterns in coffee distribution and shade vegetation have changed and discuss implications for biodiversity, ecosystem services, and livelihoods. Although overall cultivated coffee area has decreased by 8% since 1990, coffee production and agricultural intensification have increased in many places and shifted globally, with production expanding in Asia while contracting in Africa. Ecosystem services such as pollination, pest control, climate regulation, and nutrient sequestration are generally greater …

More Cells, Bigger Cells Or Simply Reorganization? Alternative Mechanisms Leading To Changed Internode Architecture Under Contrasting Stress Regimes, Heidrun Huber, Jan De Brouwer, Eric J. Von Wettberg, Heinjo J. During, Niels P.R. Anten

College of Agriculture and Life Sciences Faculty Publications

Summary: Shading and mechanical stress (MS) modulate plant architecture by inducing different developmental pathways. Shading results in increased stem elongation, often reducing whole-plant mechanical stability, while MS inhibits elongation, with a concomitant increase in stability. Here, we examined how these organ-level responses are related to patterns and processes at the cellular level by exposing Impatiens capensis to shading and MS. Shading led to the production of narrower cells along the vertical axis. By contrast, MS led to the production of fewer, smaller and broader cells. These responses to treatments were largely in line with genetic differences found among plants from …

Causality Is Logically Definable-Toward An Equilibrium-Based Computing Paradigm Of Quantum Agents And Quantum Intelligence (Qaqi), Wen-Ran Zhang, Karl E. Peace

Biostatistics Faculty Publications

A survey on agents, causality and intelligence is presented and an equilibrium-based computing paradigm of quantum agents and quantum intelligence (QAQI) is proposed. In the survey, Aristotle’s causality principle and its historical extensions by David Hume, Bertrand Russell, Lotfi Zadeh, Donald Rubin, Judea Pearl, Niels Bohr, Albert Einstein, David Bohm, and the causal set initiative are reviewed; bipolar dynamic logic (BDL) is introduced as a causal logic for bipolar inductive and deductive reasoning; bipolar quantum linear algebra (BQLA) is introduced as a causal algebra for quantum agent interaction and formation. Despite the widely held view that causality is undefinable with …