Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 2 of 2
Full-Text Articles in Plastic Surgery
Development Of A Novel Rodent Model Of Radiation-Induced Implant Capsular Contracture, Tanya Delyzer
Development Of A Novel Rodent Model Of Radiation-Induced Implant Capsular Contracture, Tanya Delyzer
Electronic Thesis and Dissertation Repository
Radiation-induced implant capsular contracture is a challenging complication of post-mastectomy breast reconstruction. The objective of this thesis was to establish a novel rodent model that replicates the critical properties of this complication. Retired breeder female Sprague-Dawley rats underwent surgery with custom smooth silicone implants placed under the right 4th mammary fat pad. Half these rats received 26Gy of ionizing radiation to the implant and fat pad. Radiated implants had both higher Baker grades of capsular contracture and Kumar scores denoting radiation-induced fibrosis. Irradiated capsules showed increased Masson’s trichrome staining and significantly higher hydroxyproline to total protein ratio compared to …
The Promotion Of Adipogenesis In A Rat Model Of Radiation-Induced Mammary Fat Pad Fibrosis, Jessica Truong
The Promotion Of Adipogenesis In A Rat Model Of Radiation-Induced Mammary Fat Pad Fibrosis, Jessica Truong
Electronic Thesis and Dissertation Repository
Radiofibrosis of the breast makes satisfactory breast tissue reconstruction challenging and is associated with complications. Autologous fat grafting can improve surgical outcomes but fat retention is variable. We developed RHAMM peptide mimetics (NPI-110) that decrease tissue fibrosis and increase mammary fat pad adipogenesis by promoting the differentiation of mesenchymal progenitor cells into adipocytes. We tested the efficacy of NPI-110 in a rat model of radiation-induced mammary fat pad fibrosis. Effects of radiation and NPI-110 were quantified by visible skin changes, fat pad volume estimates using high frequency ultrasound, mRNA expression of genes involved in fibrosis (Collagen-1:Collagen-1, TGFß1) and adipogenesis (PPARγ, …