Plastic Surgery Commons^™

An Exploration Of Facial Skin Scarring, Its Impact And Contemporary Evaluation, Michael G. Brandt

Electronic Thesis and Dissertation Repository

Facial skin cancer secondary to surgical treatment may be distressing due to the malignancy itself and from the consequences of its treatment. A visible postsurgical scar is an obvious reminder of the condition. This investigation sought to broaden our understanding of facial scarring and develop a novel tool for its objective evaluation. To this end, skin cancer as the most common etiology of facial scarring was reviewed. The scar scale literature was evaluated in the context of assessing scars through a biopsychosocial lens. Finally, the development of a novel scar scale was presented. Thirty-four individuals completed 13,056 ratings using a …

Comparing Motion Outcomes In Salvage Procedures For Wrist Arthritis, Stacy Fan

Electronic Thesis and Dissertation Repository

Scaphoidectomy and four corner fusion (4CF), and proximal row carpectomy (PRC) are salvage procedures that may be offered in advanced wrist arthritis. The optimal clinical treatment remains unclear. Biomechanical studies comparing outcomes of these procedures often only report uniplanar motion, rather than multiplanar motion which is more representative of functional wrist motion. Further, the impact of altering the relationship of the proximal and distal carpal rows in the coronal plane during 4CF has not been well-studied.

The purpose of this in-vitro biomechanical study was to quantify changes in wrist kinematics during wrist flexion-extension, radial-ulnar deviation, and circumduction in “anatomic 4CF”, …

Breast Implant-Associated Anaplastic Large Cell Lymphoma: Molecular Features, Epidemiological Risk Factors, And Evidence-Based Clinical Recommendations, Ryan Decoster

Theses and Dissertations--Clinical and Translational Science

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an emerging cancer of the immune system that can form around textured-surface breast implants. In this dissertation, the cellular and molecular mechanisms of BIA-ALCL are reviewed with a focus on the role of oncogenic JAK-STAT3 signaling in BIA-ALCL tumorigenesis and progression. Herein, the epidemiology of BIA-ALCL is systematically studied to better define the risk of BIA-ALCL and to determine the oncologic safety of smooth surface devices relative to BIA-ALCL formation. Next, a systematic review is conducted which critically appraises current clinical guidelines in order to establish an evidence base to better inform …