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Full-Text Articles in Medical Sciences
Utility Of Mri In Assessment Of Pituitary Iron Overload, Abdul Mueed Zafar, Lubna Zuberi, Ameer Hamza Khan, Humera Ahsan
Utility Of Mri In Assessment Of Pituitary Iron Overload, Abdul Mueed Zafar, Lubna Zuberi, Ameer Hamza Khan, Humera Ahsan
Medical College Documents
Beta thalassemia is highly prevalent in Pakistan with a carrier rate of 5-8%. The main complication of beta thalassemia major is iron overload, especially in reticuloendothelial system, heart, joints and endocrine glands. Pituitary siderosis leads to hypogonadotropic hypogonadism and growth hormone deficiency. Measures of plasma ferritin levels and hepatic iron level are used for assessing body iron overload but these are limited for various reasons particularly in case of pituitary siderosis. Magnetic Resonance Imaging (MRI) is a reliable, non invasive and easily available utility for assessing tissue siderosis. We assessed a 20 year old female beta thalassemic diagnosed with hypogonadotropic …
Medicinal Importance Of Grapefruit Juice And Its Interaction With Various Drugs, Jawad Kiani, Sardar Z. Imam
Medicinal Importance Of Grapefruit Juice And Its Interaction With Various Drugs, Jawad Kiani, Sardar Z. Imam
Medical College Documents
Grapefruit juice is consumed widely in today's health conscious world as a protector against cardiovascular diseases and cancers. It has however, been found to be an inhibitor of the intestinal cytochrome P - 450 3A4 system, which is responsible for the first pass metabolism of many drugs. The P - glycoprotein pump, found in the brush border of the intestinal wall which transports many of these cytochrome P - 450 3A4 substrates, has also been implicated to be inhibited by grapefruit juice. By inhibiting these enzyme systems, grapefruit juice alters the pharmacokinetics of a variety of medications, leading to elevation …
Paediatric Mental Health In Pakistan: A Neglected Avenue, Ali Jawaid, Tauseef-Ur-Rehman
Paediatric Mental Health In Pakistan: A Neglected Avenue, Ali Jawaid, Tauseef-Ur-Rehman
Medical College Documents
No abstract provided.