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Full-Text Articles in Medical Sciences
Murine Anti-Idiotype Antibody 3h1, Malaya Chatterjee, Heinz Köhler, Sunil K. Chatterjee, Kenneth A. Foon
Murine Anti-Idiotype Antibody 3h1, Malaya Chatterjee, Heinz Köhler, Sunil K. Chatterjee, Kenneth A. Foon
Microbiology, Immunology and Molecular Genetics Faculty Patents
The present invention provides a monoclonal anti-idiotype antibody 3H1 that escapes immune tolerance and elicits a specific immune response to CEA in mice, rabbits, monkeys, and patients with advanced CEA-associated disease. This invention also provides compositions which can be used in the detection or treatment of CEA-associated tumors mimics a specific epitope on carcinoembryonic antigen and a hybridoma that produces 3H1.