Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Medical Sciences
Protein Adducts Of Iso[4]Levuglandin E2, A Product Of The Isoprostane Pathway, In Oxidized Low Density Lipoprotein, Robert G. Salomon, Wei Sha, Cynthia Brame, Kamaljit Kaur, Ganesamoorthy Subbanagounder, June O'Neil, Henry F. Hoff, L. Jackson Roberts Ii
Protein Adducts Of Iso[4]Levuglandin E2, A Product Of The Isoprostane Pathway, In Oxidized Low Density Lipoprotein, Robert G. Salomon, Wei Sha, Cynthia Brame, Kamaljit Kaur, Ganesamoorthy Subbanagounder, June O'Neil, Henry F. Hoff, L. Jackson Roberts Ii
Pharmacy Faculty Articles and Research
Levuglandin (LG) E2, a cytotoxic seco prostanoic acid co-generated with prostaglandins by nonenzymatic rearrangements of the cyclooxygenase-derived endoperoxide, prostaglandin H2, avidly binds to proteins. That LGE2-protein adducts can also be generated nonenzymatically is demonstrated by their production during free radical-induced oxidation of low density lipoprotein (LDL). Like oxidized LDL, LGE2-LDL, but not native LDL, undergoes receptor-mediated uptake and impaired processing by macrophage cells. Since radical-induced lipid oxidation produces isomers of prostaglandins, isoprostanes (isoPs), via endoperoxide intermediates, we postulated previously that a similar family of LG isomers, isoLGs, is cogenerated with isoPs. Now …
K-Cl Cotransport: Membrane Immunofluorescence Localization By Confocal Microscopy Of The Kcc1 Protein, Before And After Truncation Of The Cooh-Terminal Domain, In Human Embryonic Kidney (Hek293) Cells, Peter K. Lauf, Kenneth B.E. Gagnon, Jin Zhang, Eric Delpire, Robert E.W. Fyffe, Norma C. Adragna
K-Cl Cotransport: Membrane Immunofluorescence Localization By Confocal Microscopy Of The Kcc1 Protein, Before And After Truncation Of The Cooh-Terminal Domain, In Human Embryonic Kidney (Hek293) Cells, Peter K. Lauf, Kenneth B.E. Gagnon, Jin Zhang, Eric Delpire, Robert E.W. Fyffe, Norma C. Adragna
Pharmacology and Toxicology Faculty Publications
No abstract provided.
New Mechanism Of Regulation Of K+-Cl- Cotransport, Norma C. Adragna, H. Ahmed, C. M. Ferrell, J. Filosa, Peter K. Lauf
New Mechanism Of Regulation Of K+-Cl- Cotransport, Norma C. Adragna, H. Ahmed, C. M. Ferrell, J. Filosa, Peter K. Lauf
Pharmacology and Toxicology Faculty Publications
No abstract provided.
Quantitative Analysis Of Changes In Cell Volume And Intracellular Ph Induced By Ammonia And Ammonium In Neuroblastoma Cells Studied With Fluorescent Probes, Vania D. Rosas, G. Boyarsky, S. Marquez, Francisco J. Alvarez-Leefmans
Quantitative Analysis Of Changes In Cell Volume And Intracellular Ph Induced By Ammonia And Ammonium In Neuroblastoma Cells Studied With Fluorescent Probes, Vania D. Rosas, G. Boyarsky, S. Marquez, Francisco J. Alvarez-Leefmans
Pharmacology and Toxicology Faculty Publications
No abstract provided.