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Theses and Dissertations (ETD)
Actin Polymerization; Autoimmunity; Drak2; IL-2 Signaling; T cells; Type 1 Diabetes
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The Role Of Drak2 In T Cell Function And Autoimmunity, Tarsha L. Harris
The Role Of Drak2 In T Cell Function And Autoimmunity, Tarsha L. Harris
Theses and Dissertations (ETD)
The immune system utilizes many regulatory mechanisms to limit immune responses and ensure that immune cells target foreign pathogens and not healthy cells of the body. However, some immune cells can escape these checkpoints and attack the body’s healthy cells, leading to tissue destruction and devastating autoimmune disorders. For example, multiple sclerosis (MS) occurs when immune cells attack the myelin sheath surrounding neurons of the central nervous system (CNS). Likewise, the destruction of pancreatic islet cells by dysregulated immune cells leads to type 1 diabetes (T1D). Remarkably, there are more than 80 types of autoimmune diseases. An estimated 50 million …