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Graduate Theses and Dissertations
Biological sciences; Candida albicans; Iron deficiency; Transcription factor
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Ccaat-Binding Factor As A Transcriptional Regulator Of Cyc1 In Candida Albicans, Carmen S. Padilla-Marcia
Ccaat-Binding Factor As A Transcriptional Regulator Of Cyc1 In Candida Albicans, Carmen S. Padilla-Marcia
Graduate Theses and Dissertations
Candida albicans is a normal commensal of the human flora; however, under appropriate circumstances this organism can become pathogenic to the host and cause life threatening conditions. In fact, Candida species are the fourth most common nosocomial infection in the Unites States with a mortality rate of over 30%
The CCAAT binding factor is a multi-protein transcription factor highly conserved in eukaryotes. It binds specifically to the consensus sequence 5'-CCAAT-3' in promoters and it is one of the most common cisacting elements in eukaryotes promoters. This transcription factor is composed of three DNA binding subunits; Hap2p, Hap3p and Hap5. In …