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The Role Of Serum Lipids On Cyclosporine-Inducedgingival Overgrowth In Renal Transplantpatients, Tunç İlgenli̇, Gül Ati̇lla, Mustafa Ci̇ri̇t, Nezi̇h Azmak

Turkish Journal of Medical Sciences

Cyclosporine-A (CsA) is widely used to prevent organ rejection in recipients of transplanted organs and also in the treatment of various systemic diseases. CsA has a number of side effects, including gingival overgrowth (GO). However, the pathogenesis of CsA-induced GO remains uncertain. It has been postulated that CsA alters fibroblast activity. CsA is transported in plasma by binding to lipid components. It is possible that changes in serum lipid levels could alter the interaction between the CsA and gingival fibroblasts within the gingival tissues. It has also been reported that CsA may alter serum lipid levels in the transplant population. …