Medical Sciences Commons^™

Effect Of Short-Term Use Of Testosterone Enanthate On Personality And Mood In Healthy Young Males, Rosanne Coutts, Shane Rogerson, Glen Deakin, Sonya Marshall-Gradisnik, Rudi Meir, Shi Zhou, Robert Weatherby

Sonya Marshall-Gradisnik

Supported by notions that supplementation enhances mental, physical and sexual powers steroid users focus on its ability to influence emotional state, and more profoundly shape identity. The notion of anabolic steroid hormone induced changes in biological drive, causing increased anger and hostility is anecdotal but inconclusive.

PURPOSE:

To quantify the existence of either Personality or Mood effects that may be observed during and following six weeks of the administration of controlled doses of testosterone enanthate.

METHODS: Eighteen males (25±4.0 yrs) were match paired and randomly assigned in a double blind manner to either a testosterone enanthate or placebo group. During …

Effects Of Estrogen On The Mechanical Behavior Of The Human Achilles Tendon In Vivo, Adam Bryant, Ross Clark, Simon Bartold, Aron Murphy, Kim Bennell, Erik Hohmann, Sonya Marshall-Gradisnik, Craig Payne, Kay Crossley

Sonya Marshall-Gradisnik

The purpose of this study was to elucidate the effect of normal fluctuating [nonmonophasic oral contraceptive pill (MOCP) users] and low, consistent (MOCP users) endogenous plasma estrogen levels on the strain behavior of the Achilles tendon in vivo. Twenty women (age 28.0 ± 4.2 yr, height 1.67 ± 0.07 m, mass 61.6 ± 6.8 kg) who had been using the MOCP for at least 12 mo together with 20 matched women who were non-MOCP users (age 31.9±7.3 yr, height 1.63 ± 0.05 m, mass 62.5 ± 5.9 kg) participated in this study. Non-MOCP users were tested at the time of …

Characterization Of The Α1-Adrenoceptor Subtype Mediating Contractions Of The Pig Internal Anal Sphincter, K. Mills, Natasha Hausman, Russ Chess-Williams

Russ Chess-Williams

Background and purpose: The internal anal sphincter has been shown to contract in response to a1-adrenoceptor stimulation and therefore a1-adrenoceptor agonists may be useful in treating faecal incontinence. This study characterizes the a1-adrenoceptor subtype responsible for mediating contraction of the internal anal sphincter of the pig.

Experimental approach: The potency of agonists and the affinities of several receptor subtype selective antagonists were determined on smooth muscle strips for the pig internal anal sphincter. Cumulative concentration–response curves were performed using phenylephrine and noradrenaline.

Key results: The potency of the a1A-adrenoceptor selective agonist A61603 (pEC50¼7.79±0.04) was 158-fold greater than that for noradrenaline …

Responding, Rather Than Reacting To, Race In Biomedical Research: A Response To Professors Caulfield And Mwaria, Michael J. Malinowski

Michael J. Malinowski

This Commentary is part of a colloquy on race-based genetics research.