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Full-Text Articles in Medical Sciences
Proteomic Profiling Of Serum Derived Exosomes From Prostate Cancer Patients, David Turay
Proteomic Profiling Of Serum Derived Exosomes From Prostate Cancer Patients, David Turay
Loma Linda University Electronic Theses, Dissertations & Projects
Touted among the major achievements in the diagnosis and management of Prostate cancer (PCa) in the past few decades has been, the dramatic decline of men with advanced/metastatic PCa at diagnosis coupled with a significant improvement ( >90%) in the five and ten year survival rates of the disease. Non-palpable PCa (potentially clinically treatable disease) now accounts for 70-80% of all newly diagnosed cases of PCa. Preceding these changes by about a decade was the introduction of Prostatic Specific Antigen (PSA) into clinical practice; first as biomarker for monitoring response to therapy and subsequently as a complementary screening tool. It …
Role Of Slit2 In Reducing Complications After Surgical Brain Injury, Prativa Sherchan
Role Of Slit2 In Reducing Complications After Surgical Brain Injury, Prativa Sherchan
Loma Linda University Electronic Theses, Dissertations & Projects
Surgical brain injury (SBI) is the inadvertent injury to brain tissue at the perisurgical site which occurs due to neurosurgical maneuvers such as incision, retraction, and electrocoagulation that can result in post-operative complications. Blood brain barrier (BBB) disruption and neuroinflammation are major pathophysiological consequences after neurosurgical injury. Blood brain barrier dysfunction leads to increased influx of water and plasma proteins as well as peripheral immune cell infiltration into the brain parenchyma that further potentiates brain edema and worsens post-operative neurological function. Activated resident immune cells and infiltrated peripheral immune cells release inflammatory mediators and promote oxidative stress and cell death …