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Full-Text Articles in Medical Sciences
The Effects Of Conjugated Linoleic Acid Supplementation On Lipopolysaccharide-Challenged Synoviocytes, Allison Millican
The Effects Of Conjugated Linoleic Acid Supplementation On Lipopolysaccharide-Challenged Synoviocytes, Allison Millican
All Theses
Osteoarthritis is one of the leading causes of lameness in the athletic horse. Cases of equine osteoarthritis typically present with synovitis, or inflammation of the synovium. This inflammation in the synovium leads to the production of inflammatory cytokines and eicosanoids. Although these downstream products can be beneficial, overproduction can lead to degradation of cartilage and joint disease. Opportunities to help mitigate or decrease inflammation within the joint are of current interest to the equine industry. One method being investigated is nutritional supplementation. The anti-inflammatory effects demonstrated by CLA supplementation make it a potential prospect for utilization in mitigating joint inflammation. …
The Avian Thrombocyte Is A Specialized Immune Cell, Farzana Ferdous
The Avian Thrombocyte Is A Specialized Immune Cell, Farzana Ferdous
All Dissertations
Thrombocytes are the most abundant circulating cells next to red blood cells in avian blood. Avian thrombocytes are homologous in function to mammalian platelets. Avian thrombocytes and the mammalian platelet are widely recognized contributors to inflammatory responses upon stimulation with various microbial stimulants. However, some observed responses of the avian thrombocyte depart from a standardized model ascribed to innate cells. To help unravel the role of thrombocytes in innate immunity, and possibly adaptive immunity, first we examined the surface features of chicken thrombocytes. Chicken thrombocytes constitutively express transcripts for different Toll-like receptors (TLRs) that are crucial for the innate immune …
Effects Of Creosote-Contaminated Sediment Extracts On Mouse Macrophage Physiology And Function, Rayna Silva
Effects Of Creosote-Contaminated Sediment Extracts On Mouse Macrophage Physiology And Function, Rayna Silva
All Theses
The southern branch of the Elizabeth River, at Portsmouth Virginia is one of the most polluted systems in North America. This harbor estuary system is also home to the Atlantic Wood Superfund site, which is heavily contaminated with creosote from the Atlantic Wood (AW) preservative company that ceased production in the later 1990s. Creosote is a mixture of polyaromatic hydrocarbons (PAHs), metals, and numerous aliphatic hydrocarbons, and well known to be carcinogenic. The toxicity of sediments and pore waters from the AW site has been studied extensively using Fundulus heteroclitus, also known as the mummichog, or Atlantic killifish. Most adult …