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Full-Text Articles in Medical Sciences
The Immune System In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Sonya Marshall-Gradisnik, Donald Staines
The Immune System In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Sonya Marshall-Gradisnik, Donald Staines
Sonya Marshall-Gradisnik
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a heterogeneous multifactorial disease characterised by severe fatigue and a range of systemic symptoms resulting in an ability to function at optimal levels. The symptoms of CFS/ME vary from patient to patient; however, prolonged and disabling fatigue, impaired memory and concentration and widespread pain are typical symptoms report by most patients. There is no known single causal factor associated with CFS/ME although development of the condition post-infection is common. CFS/ME may affect the nervous, immune, endocrine, muscular, cardiovascular and respiratory systems. The present chapter review research pertaining to immunological function and other related areas …
Myelopoiesis Related To Perinatal Spleen, Rebecca Hinton, Sawang Petvises, Helen O'Neill
Myelopoiesis Related To Perinatal Spleen, Rebecca Hinton, Sawang Petvises, Helen O'Neill
Helen O'Neill
Adult murine spleen is known to have a major role in the development of dendritic cell (DC) subsets, including conventional DC and plasmacytoid DC. In this lab, long-term cultures (LTCs) established from murine spleen support continuous production of novel dendritic-like cells, termed LTC-DC. An in vivo equivalent subset also exists in spleen, namely L-DC. As co-cultures using LTC-derived splenic stroma support the outgrowth of L-DC from spleen and bone marrow sources, it is likely that spleen represents an important niche for DC development. To investigate the appearance of L-DC during ontogeny, spleen was isolated from embryonic and neonatal mice of …