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Full-Text Articles in Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Evaluation Of Recurrence Risks For Left-Sided Cardiac Lesions, Sarah Swain
Evaluation Of Recurrence Risks For Left-Sided Cardiac Lesions, Sarah Swain
Dissertations & Theses (Open Access)
It is widely accepted that hypoplastic left heart syndrome (HLHS), aortic valve stenosis with or without bicuspid aortic valve (AS/BAV) and coarctation of the aorta (CoA) occur in families more commonly with each other than with any other congenital heart defect (CHD). Genetic counseling for CHDs is currently based on empiric risk estimates derived from data collected on all types of CHDs between 1968 and 1990. Additionally, for the specific group of defects described above, termed left-sided lesions, estimates are available for sibling recurrence. Utilizing family history data from 757 probands recruited between 1997 and 2007 from The Children’s Hospital …