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Outcomes Of Allogeneic Hematopoietic Stem Cell Transplantation For Gata2 And Dock8 Immunodeficiencies: Demographics And Transplantation Variables, Kristen M. Cole, Dnp, Msn, Rn, Bmtcn, Ocn
Outcomes Of Allogeneic Hematopoietic Stem Cell Transplantation For Gata2 And Dock8 Immunodeficiencies: Demographics And Transplantation Variables, Kristen M. Cole, Dnp, Msn, Rn, Bmtcn, Ocn
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Background/Purpose: GATA2 and Dedicator-of-Cytokinesis-8 (DOCK8) deficiencies are two recently described genetic immunodeficiency diseases for which allogeneic hematopoietic stem cell transplant (HSCT) represents the only definitive therapy. The patient characteristics and HSCT variables that relate to the outcomes in these two diseases following HSCT remain unclear. Therefore, we described these variables in these two patient populations and explored their relationships with HSCT outcomes.
Methods: Data were obtained from retrospective chart reviews of all patients with GATA2 deficiency and DOCK8 deficiency who underwent HSCT on clinical research protocols at the National Cancer Institute. The outcomes included overall and disease-free survival status, graftversus-host …