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Reducing The Rate Of Misdiagnosis Of Postural Orthostatic Tachycardia Syndrome, Isabelle C. Gill
Reducing The Rate Of Misdiagnosis Of Postural Orthostatic Tachycardia Syndrome, Isabelle C. Gill
Honors Undergraduate Theses
Postural orthostatic tachycardia syndrome (POTS) is a common yet frequently misdiagnosed dysautonomia characterized by a significant increase in heart rate upon standing. POTS patients experience severe fatigue, dizziness, pre-syncope, and a diminished quality of life. The intent of this thesis is to investigate factors contributing to POTS misdiagnosis and develop a proposal for improving diagnostic procedures. The first part of this thesis presents an overview of other frequently misdiagnosed conditions, providing an understanding of the basis for the diagnostic problems in POTS and methods to combat such difficulties. The second part of this thesis details a meta-analysis performed on POTS …
Investigating The Role Of The Gut Microbiome In Huntington Disease, Casey G. Hart
Investigating The Role Of The Gut Microbiome In Huntington Disease, Casey G. Hart
Honors Undergraduate Theses
Huntington disease (HD) is an inherited neurodegenerative disease caused by a trinucleotide repeat expansion in the huntingtin (HTT) gene. Metabolic dysfunction is a feature of HD that is recapitulated in HD mouse models. Our lab has shown that circadian feeding rhythms are disrupted in humanized HD mice and restored by suppression of brain HTT. Furthermore, when circadian feeding rhythm is artificially restored, in addition to normalization of metabolic function, liver and striatal HTT is temporarily reduced, demonstrating that HTT is involved in gut-brain feedback. The gut microbiome, which can regulate gut-brain feedback, has been implicated in the pathogenesis …