Diseases Commons^™

Il-10 And Alveolar Bone Loss, Abdulaziz Saud Al-Rasheed

Loma Linda University Electronic Theses, Dissertations & Projects

Interleukin-10 (IL-10) is a cytokine with anti-inflammatory activities. IL-10 knockout (KO) mice exhibit severe intestinal inflammation in the presence of normal gut flora. We hypothesized that IL-10 KO mice would also be susceptible to inflammatory periodontal disease resulting in alveolar bone loss (ABL). The purpose of this study was to compare naturally occurring ABL in IL-10 KO and wild type (WT) mice. Twelve IL-10 KO and 12 WT mice, age-(7 months) and sex-(male) matched, were used. Half of the mice were on 129/SvEv and half on C57BL/6J background. Animal heads were defleshed and treated to remove all organic material. ABL …

Periodontal Repair In Dogs : Effect Of Recombinant Human Transforming Growth Factor Beta-1 On Guided Tissue Regeneration, Saghi Shayan Razi

Loma Linda University Electronic Theses, Dissertations & Projects

The objective of this study was to evaluate bone and cementum regeneration in the critical size, supraalveolar, periodontal defect model following surgical implantation of recombinant human transforming growth factor beta-1 (rhTGFß-1) in conjunction with guided tissue regeneration (GTR). Five male beagle dogs were used in a split-mouth design. Alternate jaw quadrants in consecutive animals received GTR with rhTGFß-1 in a resorbable calcium carbonate carrier. Contralateral jaw quadrants received GTR with carrier only (control). The healing interval was 4 weeks. Clinical healing was generally uneventful, however, minor membrane exposures were observed for both treatments with limited gingival inflammation. All defects with …

Periodontal Repair In Dogs : Part I : Evaluation Of The Natural Disease Model ; Part Ii : Eptfe Barrier Membranes Support Wound Stabilization And Enhance Bone Regeneration, James Marc Haney

Loma Linda University Electronic Theses, Dissertations & Projects

Animal models are frequently consulted for histometric analysis of reconstructive periodontal therapy. Statistical analysis of induced lesion defects and surgically created defects from our laboratory suggest defect size homogeneity is critical for the model to discriminate treatment effects. This study characterizes natural disease defects in beagle dogs. Buccal-lingual histologic sections from the 2nd, 3rd, and 4th mandibular premolar teeth (P2, P3, P4) from 6 aged beagle dogs with natural disease defects were evaluated for variation in defect height between pair matched tooth types, and jaw quadrants, as well as estimated confidence intervals for treatment differences between left and right pair …

The Periodontal Intraosseous Defect Following Root Conditioning With Citric Acid And Wound Closure Including A Ptfe Membrane : An Experimental Study, Betty Glaser Kersten

Loma Linda University Electronic Theses, Dissertations & Projects

Treatment of the intrabony or intraosseous periodontal defect has rendered much attention over the last few decades. Numerous approaches have been advocated; however, overall comparisons between treatments do not exist. This review summarizes and discusses outcomes of therapeutic modalities in the intrabony periodontal lesion from controlled clinical studies. The modalities reviewed include scaling and root planning, gingival flap surgery, gingival flap surgery including wound closure with interdental denudation, root-biomodification, placement of autologous, allogenic, or xenogeneic bone grafts, placement of alloplastic grafts, and placement of tissue guiding barrier membranes. In addition histologic observations of healing in the intrabony periodontal lesion are …

Treatment Of Periodontal Furcation Defects, Michael Martin, Bernard Gantes

Loma Linda University Electronic Theses, Dissertations & Projects

[Note: Three parts in one.]

I. Review of the Literature and Description of a Regeneration Surgical Technique

This report provides an abbreviated review of the literature on treatment and prognosis of periodontal furcation lesions. In addition, it describes a surgical technique designed to accomplish bone regeneration in class II furcation defects, together with the rationale for the development of this procedure. Results of treatment of 30 defects with this technique are presented in a subsequent report (Gantes et al. 1987).

II. Bone Regeneration in Mandibular Class II Defects

A total of 30 mandibular, buccal class II furcation defects were treated …

Effects Of Oral Hygiene Measures On Clinical And Microbiological Parameters Of Periodontal Disease, Bruno Loos

Loma Linda University Electronic Theses, Dissertations & Projects

The effects of a 12-week period of oral hygiene alone on gingival conditions and subgingival microflora in 15 patients with severe periodontitis were investigated. In addition, subgingival microsamples were compared during this oral hygiene phase with those obtained 1 week after debridement. Clinical measurements and subgingival samples from selected sites were taken at week 0 (baseline), week 6, and week 12. Microbial samples were also taken at week 13, that is, one week following debridement. At week 0 the patients were instructed in supragingival plaque control and at week 6 the hygiene regimen was supplemented with the subgingival use of …

Developing A Periodontal Screening Examination, Jeffrey R. Morgulis

Loma Linda University Electronic Theses, Dissertations & Projects

Periodontal disease is the primary cause of tooth loss in the adult, and therefore, early diagnosis of periodontal disease by the general practitioner is important in terms of prevention as well as treatment. The present study was designed to develop a periodontal screening examination which would fulfill the following requirements:

1. It should utilize precise and easily understood criteria.
2. It should take a short period of time.
3. It should enable the practitioner to accurately place patients into various disease categories.
4. It should enable the practitioner to easily and quickly relate these disease categories to treatment.

A "comprehensive" periodontal examination was performed …

Microscopic Evaluation Of Topically Applied Chlorhexidine Gluconate On Gingival Wound Healing In Dogs, Robert C. Hirst

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to evaluate microscopically the effect of topically applied 2% chlorhexidine gluconate on the healing of gingival wounds in dogs.

One week after the teeth were scaled and polished, seven experimental wound sites were prepared in the facial gingiva adjacent to the four premolars on each side of the maxillary arch in six young Labrador dogs. From this point the dogs were fed a soft plaque-inducing diet. Chlorhexidine solution was applied daily to either the right or left maxillary premolars while on the opposite side of the arch in three dogs the first and second …

A Clinical And Microscopic Evaluation Of Plaque Removal And By The Hydrodent Brush, Soertini E. Lambri

Loma Linda University Electronic Theses, Dissertations & Projects

The Hydrodent toothbrush was compared to conventional toothbrush (Lactona # 19) in its effectiveness on removing the plaque, eliminating the pocket depth, and improving the gingival tissue condition.

Forty six male and female subjects with the age range of 18 to 50 years old participated in a 5 month study with 4 week intervals. Each subject received a Hydrodent brush of soft, medium, and hard textures and a conventional toothbrush. The toothbrushes were given randomly and the subject served as his own control.

Clinical and histological evaluations were made after the use of each toothbrush. The clinical evaluation showed some …

Periodontal Pocket Reduction Following Gingival Curettage, Robert B. Tandy

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to evaluate pocket reduction following gingival curettage. The effects of temporary pressure packing, inflammation, oral hygiene, pocket depth, age and sex of the patient were evaluated.

Three hundred twenty-eight periodontal pockets were studied in forty-one adult patients selected with interdental lesions ranging from 3.0 - 7.5 mm. in depth. Pocket depth and gingival height were measured preoperatively, one month postoperatively and two months postoperatively. The mean change in pocket depth and gingival height was calculated and statistical significance was determined for all measurements.

The results show that after a two-month postoperative evaluation following gingival …

The Pathogenesis Of Periodontal Disease And Treatment Implications, Richard C. Oliver

Loma Linda University Electronic Theses, Dissertations & Projects

Presently accepted concepts of the etiology and pathogenesis of periodontal disease do not adequately explain the following consistent clinical observations: (1) equal local etiologic factors do not result in equal periodontal destruction in all patients; and, (2) equal therapy is not equally successful in all patients. The differences in patient response must be due to differences within the patient. By relating the broadened concept of disease, as described by Engel, to periodontal disease, the reasons for these individual patient differences become apparent. This concept consideres[sic] disease in relation to the patient's genie and developmental background, as well as the present …