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Virus-Host Co-Evolution: Determining The Origin Of Human Cytomegalovirus Us27 And Us28, Jessica A. Scarborough, Juliet Spencer, John Paul
Virus-Host Co-Evolution: Determining The Origin Of Human Cytomegalovirus Us27 And Us28, Jessica A. Scarborough, Juliet Spencer, John Paul
Creative Activity and Research Day - CARD
G protein-coupled receptors (GPCR) are the largest family of cell surface proteins, found in organisms from yeast to humans. Human cytomegalovirus (HCMV) is a widespread pathogen that is particularly skilled at evading immune detection and defense mechanisms, largely due to extensive co-evolution with its host’s immune system. One aspect of this co-evolution involves the acquisition of four virally encoded GPCR homologs: US27, US28, UL33 and UL78. In this research, phylogenetic analysis was used to investigate the origins of the US27 and US28 genes, which are adjacent in the viral genome. The results indicate that both US27 and US28 share the …
Torn Between Two Diseases: Changes In Tgfβ Signaling Prevents Diabetes But Promotes Neuropathy, Vasalya Panchumarthi
Torn Between Two Diseases: Changes In Tgfβ Signaling Prevents Diabetes But Promotes Neuropathy, Vasalya Panchumarthi
Creative Activity and Research Day - CARD
Type 1 diabetes (T1D) is an autoimmune disease that affects millions of children and adults worldwide. In this disease, white blood cells (Leukocytes) invade, attack, and destroy the Islets of Langerhans in the pancreas, resulting in increased blood glucose levels. Patients with T1D must use exogenous insulin injections, which can lead to many side effects over the lifespan of the person. Therefore, understanding the pathogenesis of this disease is crucial to develop new treatments for patients. The non-obese diabetic (NOD) mouse is a rodent model of T1D as well as other autoimmune diseases such as Sjogren’s syndrome, where immune cells …