Diseases Commons^™

Association Study: Apoe Alleles Association With Neurodegenerative Disorders In The Hispanic Population, Kimberly Moreno

Theses and Dissertations

The purpose of this study was to assess the impact of phenotypic variables and Apolipoprotein E (APOE) alleles and its effect on cognitive statues. APOE is a gene found vastly in the Hispanic community, speculated to be linked to neurodegenerative disorders such as Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI). Compared demographic, clinical, and genetic features among Hispanics who were diagnosed with Alzheimer's Disease, Mild Cognitive Impairment, and psychiatric disorders (e.g., anxiety and depression) in the efforts to assess the role of APOE. In past research, APOE has been considered a pathological hallmark for neurological diseases.

Past research has …

Nighttime Blood Pressure Interacts With Apoe Genotype To Increase The Risk Of Incident Dementia Of The Alzheimer’S Type In Hispanics, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Ciro Gaona, Carlos A. Chavez, Gustavo E. Calmon, Egle R. Silva, Gabriel A. De Erausquin, Mario Gil, Luis J. Mena, Joseph D. Terwilliger, Humberto Arboleda, Nikolaos Scarmeas, Joseph H. Lee, Gladys E. Maestre

School of Medicine Publications and Presentations

Background: Dementia of the Alzheimer’s type (DAT) impacts Hispanics disproportionately, with almost a twofold elevated risk of developing DAT, as well as earlier onset of the disease, than in non-Hispanic Whites. However, the role of main risk factors for DAT, such as APOE ɛ4 and blood pressure (BP) levels, remains uncertain among Hispanics.

Objective: To investigate the association of APOE ɛ4 and BP levels, measures with 24 h ambulatory BP monitoring, with incidence of DAT in an elderly cohort of Hispanics.

Methods:1,320 participants from the Maracaibo Aging Study, free of dementia at the baseline, and with ambulatory BP …