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Full-Text Articles in Diseases
Neuropsychiatric Symptoms Among Hispanics: Results Of The Maracaibo Aging Study, Mario Gil, Ney Alliey-Rodriguez, Juan Carlos Lopez Alvarenga, Vincent P. Diego, Ciro Gaona, Ledys Mata, Rosa V. Pirela, Carlos A. Chavez, Gabriel A. De Erausquin, Jesus D. Melgarejo, Gladys E. Maestre
Neuropsychiatric Symptoms Among Hispanics: Results Of The Maracaibo Aging Study, Mario Gil, Ney Alliey-Rodriguez, Juan Carlos Lopez Alvarenga, Vincent P. Diego, Ciro Gaona, Ledys Mata, Rosa V. Pirela, Carlos A. Chavez, Gabriel A. De Erausquin, Jesus D. Melgarejo, Gladys E. Maestre
School of Medicine Publications and Presentations
Background:
Neuropsychiatric symptoms play an important role in diagnosing and clinical follow-up of cognitive impairment and dementia.
Objective:
We investigated the relationship between neuropsychiatric symptoms, cognitive impairment, and dementia in Hispanics.
Methods:
We included 529 participants (age ≥40 years) from the Maracaibo Aging Study with standardized neuropsychiatric assessments, including the Neuropsychiatric Inventory (NPI). Based on the Clinical Dementia Rating and the Mini-Mental State Examination scores, participants’ cognitive status was categorized into normal cognition, mild/moderate, and severe cognitive impairment. Diagnosis of dementia was established in a consensus conference. Statistical analyses included multivariable logistic regression models and area under the curve (AUC). …
A White Matter Connection Of Schizophrenia And Alzheimer’S Disease, Peter Kochunov, Artemis Zavaliangos-Petropulu, Neda Jahanshad, Paul M. Thompson, Meghann C. Ryan, Joshua Chiappelli, Shuo Chen, Xiaoming Du, Kathryn Hatch, Bhim Adhikari, Joanne E. Curran, John Blangero
A White Matter Connection Of Schizophrenia And Alzheimer’S Disease, Peter Kochunov, Artemis Zavaliangos-Petropulu, Neda Jahanshad, Paul M. Thompson, Meghann C. Ryan, Joshua Chiappelli, Shuo Chen, Xiaoming Du, Kathryn Hatch, Bhim Adhikari, Joanne E. Curran, John Blangero
School of Medicine Publications and Presentations
Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for developing Alzheimer’s disease (AD). Both SZ and AD have white matter abnormalities and cognitive deficits as core disease features. We hypothesized that aging in SZ patients may be associated with the development of cerebral white matter deficit patterns similar to those observed in AD. We identified and replicated aging-related increases in the similarity between white matter deficit patterns in patients with SZ and AD. The white matter “regional vulnerability index” (RVI) for AD was significantly higher in SZ patients compared with healthy controls in both the independent …
Nighttime Blood Pressure Interacts With Apoe Genotype To Increase The Risk Of Incident Dementia Of The Alzheimer’S Type In Hispanics, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Ciro Gaona, Carlos A. Chavez, Gustavo E. Calmon, Egle R. Silva, Gabriel A. De Erausquin, Mario Gil, Luis J. Mena, Joseph D. Terwilliger, Humberto Arboleda, Nikolaos Scarmeas, Joseph H. Lee, Gladys E. Maestre
Nighttime Blood Pressure Interacts With Apoe Genotype To Increase The Risk Of Incident Dementia Of The Alzheimer’S Type In Hispanics, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Ciro Gaona, Carlos A. Chavez, Gustavo E. Calmon, Egle R. Silva, Gabriel A. De Erausquin, Mario Gil, Luis J. Mena, Joseph D. Terwilliger, Humberto Arboleda, Nikolaos Scarmeas, Joseph H. Lee, Gladys E. Maestre
School of Medicine Publications and Presentations
Background: Dementia of the Alzheimer’s type (DAT) impacts Hispanics disproportionately, with almost a twofold elevated risk of developing DAT, as well as earlier onset of the disease, than in non-Hispanic Whites. However, the role of main risk factors for DAT, such as APOE ɛ4 and blood pressure (BP) levels, remains uncertain among Hispanics.
Objective: To investigate the association of APOE ɛ4 and BP levels, measures with 24 h ambulatory BP monitoring, with incidence of DAT in an elderly cohort of Hispanics.
Methods:1,320 participants from the Maracaibo Aging Study, free of dementia at the baseline, and with ambulatory BP …
Incidence Of Dementia In Elderly Latin Americans: Results Of The Maracaibo Aging Study, Gladys E. Maestre, Luis J. Mena, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Gloria Pino-Ramírez, Milady Urribarrí, Inara J. Chacon, Carlos A. Chavez, Luis Falque-Madrid, Ciro A. Gaona
Incidence Of Dementia In Elderly Latin Americans: Results Of The Maracaibo Aging Study, Gladys E. Maestre, Luis J. Mena, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Gloria Pino-Ramírez, Milady Urribarrí, Inara J. Chacon, Carlos A. Chavez, Luis Falque-Madrid, Ciro A. Gaona
School of Medicine Publications and Presentations
Introduction—There are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study (MAS) to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans.
Methods—The DSM IV-R was used to diagnose dementia, which was classified as Alzheimer’s disease (AD), vascular dementia (VaD), or other. Age- and sex-specific incidence was estimated as the number of new cases of dementia divided by person-years of follow-up (p-y).
Results—The incidence of all dementia diagnoses was 9.10 per 1000 p-y (95% CI 7.13–11.44; 8026 total p-y), 5.18 for AD (95% CI 3.72–7.03; …
Characterization Of Continuously Oscillating Neurons (Cons) Of The Medial Septum Of Rats, Nadia Noel Carreon
Characterization Of Continuously Oscillating Neurons (Cons) Of The Medial Septum Of Rats, Nadia Noel Carreon
Theses and Dissertations - UTB/UTPA
Theta oscillation is the largest extracellular synchronous signal that can be recorded from the mammalian brain. It is known to influence information retention in the hippocampus, which plays a key role in declarative memory, recognition memory, working memory, and spatial memory. The theta oscillation field frequency is between 3 and 12 Hz and is present during exploratory behavior and sleep in rodents. Theta rhythm in the hippocampus is postulated to be produced by the rhythmical activity of pacemaking cells in the medial septumvertical limb of the diagonal band of Broca (MS-vDBB). Previous work in our laboratory demonstrated the existence of …
Building Capacity For Dementia Care In Latin America And The Caribbean, Francisco J. Gonzalez, Ciro Gaona, Marialcira Quintero, Carlos A. Chavez, Joyce Selga, Gladys E. Maestre
Building Capacity For Dementia Care In Latin America And The Caribbean, Francisco J. Gonzalez, Ciro Gaona, Marialcira Quintero, Carlos A. Chavez, Joyce Selga, Gladys E. Maestre
School of Medicine Publications and Presentations
Latin America and the Caribbean (LAC) have limited facilities and professionals trained to diagnose, treat, and support people with dementia and other forms of cognitive impairment. The situation for people with dementia is poor, and worsening as the proportion of elderly in the general population is rapidly expanding. We reviewed existing initiatives and provided examples of actions taken to build capacity and improve the effectiveness of individuals, organizations, and national systems that provide treatment and support for people with dementia and their caregivers. Regional barriers to capacity building and the importance of public engagement are highlighted. Existing programs need to …
Biological Basis For Cerebral Dysfunction In Schizophrenia In Contrast With Alzheimer’S Disease, Rodrigo O. Kuljis, Luis V. Colom, Leonel E. Rojo
Biological Basis For Cerebral Dysfunction In Schizophrenia In Contrast With Alzheimer’S Disease, Rodrigo O. Kuljis, Luis V. Colom, Leonel E. Rojo
Health & Biomedical Sciences Faculty Publications and Presentations
Schizophrenia and Alzheimer’s disease are two disorders that, while conceptualized as pathophysiologically and clinically distinct, cause substantial cognitive and behavioral impairment worldwide, and target apparently similar – or nearby – circuitry in regions such as the temporal and frontal lobes.We review the salient differences and similarities from selected historical, nosological, and putative mechanistic viewpoints, as a means to help both clinicians and researchers gain a better insight into these intriguing disorders, for which over a century of research and decades of translational development was needed to begin yielding treatments that are objectively effective, but still very far from entirely satisfactory. …