Diseases Commons^™

Association Study: Apoe Alleles Association With Neurodegenerative Disorders In The Hispanic Population, Kimberly Moreno

Theses and Dissertations

The purpose of this study was to assess the impact of phenotypic variables and Apolipoprotein E (APOE) alleles and its effect on cognitive statues. APOE is a gene found vastly in the Hispanic community, speculated to be linked to neurodegenerative disorders such as Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI). Compared demographic, clinical, and genetic features among Hispanics who were diagnosed with Alzheimer's Disease, Mild Cognitive Impairment, and psychiatric disorders (e.g., anxiety and depression) in the efforts to assess the role of APOE. In past research, APOE has been considered a pathological hallmark for neurological diseases.

Past research has …

Characterization Of Continuously Oscillating Neurons (Cons) Of The Medial Septum Of Rats, Nadia Noel Carreon

Theses and Dissertations - UTB/UTPA

Theta oscillation is the largest extracellular synchronous signal that can be recorded from the mammalian brain. It is known to influence information retention in the hippocampus, which plays a key role in declarative memory, recognition memory, working memory, and spatial memory. The theta oscillation field frequency is between 3 and 12 Hz and is present during exploratory behavior and sleep in rodents. Theta rhythm in the hippocampus is postulated to be produced by the rhythmical activity of pacemaking cells in the medial septumvertical limb of the diagonal band of Broca (MS-vDBB). Previous work in our laboratory demonstrated the existence of …

Correlation Of Amyloid Beta And Spatial Learning And Memory Deficits On A Thy1-App Mouse Model For Alzheimer's Disease, Amber Lynn Betz

Theses and Dissertations - UTB/UTPA

The McGill-Thy1 APP mouse is a triple transgenic model of Alzheimer disease, which has the mutant amyloid precursor protein to synergistically over-produce amyloid beta plaques. These mice exhibit visuo-spatial learning impairment at 3 months of age and memory impairment at 10-13 months of age in the Morris water maze. To extend these findings mice at 3, 5, and 7 months of age were tested on the Barnes maze. Non-Transgenic and Transgenic mice showed improvement during acquisition. However, 3 month and 5 month McGill Thy1- APP mice showed impaired acquisition learning while 7 month showed a learning and memory deficit compared …

The Relationship Between Health Attitudes, Beliefs, Health Locus Of Control And Use Of Breast Cancer Screening Modalities In Elderly Hispanic Women, Debra Kay Gillett, Rosamaria Ortiz

Theses and Dissertations - UTB/UTPA

A non-experimental design was used to examine the relationship between health attitudes, beliefs, locus of control and the use of breast cancer screening modalities in elderly Hispanic women in this pilot study. Leininger's Theory of Culture Care Diversity and Universality and the Health Belief Model were the supporting theoretical frameworks. Research was conducted at the Amigos del Valle senior centers in Hidalgo County and included 52 English-speaking elderly Hispanic volunteer participants. Instruments used for data collection were the Health Care Attitudes and Beliefs Scale and the Multidimensional Health Locus of Control Scale. Results of this study revealed that there appears …

A Comparison Of The Effects Of Moderate- And High-Carbohydrate Diets On Coronary Heart Disease Risk Factors: A Pilot Study, Margaret Helen Fernandez, Julia Ava Niehaus Soper

Theses and Dissertations - UTB/UTPA

This pilot study compared the effects of two diets on total cholesterol to high- density lipoprotein cholesterol ratio, body mass index, and waist circumference. A diet of 15% protein, 55% or more carbohydrate, and 30% or less fat was compared to a diet of 30% protein, 40% carbohydrate, and 30% fat. Lipid levels and anthropometric measurements were obtained on 18 adult males with moderately elevated lipid levels before and after 12 weeks of dietary intervention. Analyses showed variances between and within the study groups in the areas of anthropometric measurements and lipid levels; no statistically significant differences between the groups …