Diseases Commons^™

Identification Of Flock House Virus Cell Surface Receptor Protein(S) Using Affinity Chromatography And Chemical Cross-Linking, Kristen Delwiche

Summer Research

The mechanism for non-enveloped virus host-cell penetration remains poorly understood. Flock House Virus (FHV), a small insect virus that infects Drosophila melanogaster cells in tissue culture, is an excellent model system for studying how non-enveloped viruses enter and infect cells. There is a wealth of high-resolution structural information available, and it is simple, consisting only of two single-stranded RNA genome segments surrounded by an icosahedral protein capsid. In this study, chemical-cross-linking and affinity chromatography were used to search for candidate receptor proteins for FHV. Several candidate proteins were identified, but the results remain inconclusive and additional research is required to …