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Articles 1 - 30 of 32
Full-Text Articles in Dentistry
A Glassy Carbon Electrode Modified With Reduced Graphene Oxide And Gold Nanoparticles For Electrochemical Aptasensing Of Lipopolysaccharides From Escherichia Coli Bacteria, Mehrab Pourmadadi, Javad Shabani Shayeh, Meisam Omidi, Fatemeh Yazdian, Masoud Alebouyeh, Lobat Tayebi
A Glassy Carbon Electrode Modified With Reduced Graphene Oxide And Gold Nanoparticles For Electrochemical Aptasensing Of Lipopolysaccharides From Escherichia Coli Bacteria, Mehrab Pourmadadi, Javad Shabani Shayeh, Meisam Omidi, Fatemeh Yazdian, Masoud Alebouyeh, Lobat Tayebi
School of Dentistry Faculty Research and Publications
An electrochemical aptasensor is described for the voltammetric determination of lipopolysaccharide (LPS) from Escherichia coli 055:B5. Aptamer chains were immobilized on the surface of a glassy carbon electrode (GCE) via reduced graphene oxide and gold nanoparticles (RGO/AuNPs). Fast Fourier transform infrared, X-ray diffraction and transmission electron microscopy were used to characterize the nanomaterials. Cyclic voltammetry, square wave voltammetry and electrochemical impedance spectroscopy were used to characterize the modified GCE. The results show that the modified electrode has a good selectivity for LPS over other biomolecules. The hexacyanoferrate redox system, typically operated at around 0.3 V (vs. Ag/AgCl) is used as …
Design Of A New 3d‐Printed Joint Plug, Lobat Tayebi, Zhanfeng Cui, Hua Ye
Design Of A New 3d‐Printed Joint Plug, Lobat Tayebi, Zhanfeng Cui, Hua Ye
School of Dentistry Faculty Research and Publications
This paper introduces a kit of parts as a novel three‐dimensional (3D)–printed joint plug, in which each of the parts function cooperatively to treat cartilage damage in joints of the human body (e.g., hips, wrists, elbow, knee, and ankle). Three required and one optional parts are involved in this plug. The first part is a 3D‐printed hard scaffold (bone portion) to accommodate bone cells, and the second is a 3D‐printed soft scaffold (cartilage portion) overlying the bone portion to accommodate chondrocytes. The third part of joint plug is a permeable membrane, termed film, to cover the entire plug to provide …
Synthesis And Application Of Ce-Doped Tio2 Nanoparticles Loaded On Activated Carbon For Ultrasound-Assisted Adsorption Of Basic Red 46 Dye, Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram, Fatemah Mehrabi, Ali Akbar Bazrafshan, Lobat Tayebi
Synthesis And Application Of Ce-Doped Tio2 Nanoparticles Loaded On Activated Carbon For Ultrasound-Assisted Adsorption Of Basic Red 46 Dye, Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram, Fatemah Mehrabi, Ali Akbar Bazrafshan, Lobat Tayebi
School of Dentistry Faculty Research and Publications
Ce was doped on TiO2 nanoparticles (NPs), and this association was loaded on activated carbon (Ce-TiO2-NPs-AC). The characterization was completed by FE-SEM, TEM, and XRD, and finally these NPs were used for the ultrasonic-assisted adsorption of Basic Red 46 (BR 46) from aqueous solution. An experimental model suggested by the central composite design (CCD)—as a branch of response surface methodology (RSM)—provides insight into the influence of variables, such as BR 46 concentration, pH, adsorbent mass, and sonication time, on BR 46 removal. Experimental results revealed that setting conditions at 25 mg L−1 of BR 46, pH …
Conductive Nanofibrous Chitosan/Pedot:Pss Tissue Engineering Scaffolds, Ali Abedi, Mahdi Hasanzadeh, Lobat Tayebi
Conductive Nanofibrous Chitosan/Pedot:Pss Tissue Engineering Scaffolds, Ali Abedi, Mahdi Hasanzadeh, Lobat Tayebi
School of Dentistry Faculty Research and Publications
Design of a proper scaffold is the first step in fabrication of a tissue engineering product, which should be able to support cellular growth in in vitro conditions. This study focuses on the fabrication and characterization of chitosan (CS) scaffolds containing PEDOT:PSS, a conductive polymer. The scaffold is primarily designed for cardiac tissue engineering, although it can be used for other applications too. Chitosan scaffolds containing 0.3, 0.6 and 1 wt% of PEDOT:PSS are fabricated through electrospinning. The structure and morphology of scaffolds are characterized by scanning electron microscopy (SEM), 3D Laser Measuring Microscopy and Fourier-transform infrared spectroscopy (FTIR). The …
Matrix Metalloproteinases And Temporomandibular Joint Disorder: A Review Of The Literature, Logan Herm, Ardit Haxhia, Flavio Camejo, Lobat Tayebi, Luis Eduardo Almeida
Matrix Metalloproteinases And Temporomandibular Joint Disorder: A Review Of The Literature, Logan Herm, Ardit Haxhia, Flavio Camejo, Lobat Tayebi, Luis Eduardo Almeida
School of Dentistry Faculty Research and Publications
Temporomandibular disorders (TMD) are progressive degenerative disorders that affect the components of the temporomandibular joint (TMJ), characterized by pain and limitations in function. Matrix metalloproteinases (MMP) are enzymes involved in physiological breakdown of tissue that can have a pathological effect from an increase in activity during inflammation. A PubMed search of the current literature (within the past 10 years) was conducted to identify human studies involving matrix metalloproteinases activity in TMJ components of patients with TMD. Two separate searches results in 34 studies, six of which met inclusion criteria. Immunohistochemistry and gene analysis were used to evaluate MMP expression in …
A Graphene Based–Biomimetic Molecularly Imprinted Polyaniline Sensor For Ultrasensitive Detection Of Human Cardiac Troponin T(Ctnt), Meysam Karimi, Mohammad Rabiee, Mohammadreza Tahriri, Reza Salarian, Lobat Tayebi
A Graphene Based–Biomimetic Molecularly Imprinted Polyaniline Sensor For Ultrasensitive Detection Of Human Cardiac Troponin T(Ctnt), Meysam Karimi, Mohammad Rabiee, Mohammadreza Tahriri, Reza Salarian, Lobat Tayebi
School of Dentistry Faculty Research and Publications
In the present work, a biomimetic nano-molecularly imprinted polymer (N-MIP) electrode based on a graphene screen-printed electrode was developed for the ultrasensitive detection of cardiac troponin T (cTnT). The biomimetic cavities for targeted sensing for analyte were fabricated by the electropolymerization of conductive co-polymer matrix of aniline and carboxylated aniline on the graphene oxide (GO) electrode, in the presence template protein (cTnT for cardiac troponin T probe) by cyclic voltammetry. The surface characterization of the sensor was performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV), and scanning electron microscopy (SEM). The best biomimetic surface nanotexture was obtained at …
Self-Assembling Of Graphene Oxide On Carbon Quantum Dot Loaded Liposomes, Mohadeseh Hashemi, Javad Mohammadi, Meisam Omidi, Hugh D.C. Smyth, Bharadwaj Muralidharan, Thomas E. Milner, Amir Yadegari, Davoud Ahmadvand, Mohammad Shalbaf, Lobat Tayebi
Self-Assembling Of Graphene Oxide On Carbon Quantum Dot Loaded Liposomes, Mohadeseh Hashemi, Javad Mohammadi, Meisam Omidi, Hugh D.C. Smyth, Bharadwaj Muralidharan, Thomas E. Milner, Amir Yadegari, Davoud Ahmadvand, Mohammad Shalbaf, Lobat Tayebi
School of Dentistry Faculty Research and Publications
This paper describes the design of stimuli-sensitive theranostic nanoparticles, composed of reduced graphene oxide (rGO) self-assembled on thermosensitive liposomes encapsulated doxorubicin (DOX) and carbon quantum dot (CQD) (CQD-DOX-rGO-Tlip). The rGO-Tlip particles have been observed to be flower-shaped objects. The thermoresponsive and theranostic potential of CQD-DOX-rGO-Tlips have been studied using differential scanning calorimetry (DSC), ultraviolet visible spectroscopy (UV–Vis), Raman spectroscopy and photoluminescent assays. The chemo-photothermal potential of rGO–Tlip on MD-MB-231 cells during NIR laser irradiation has been examined using MTT assay. Also, the ability of rGO–Tlip to be taken up by MD-MB-231 cells has been studied using confocal microscopy and flowcytometry. …
Gene Therapy In Rheumatoid Arthritis: Strategies To Select Therapeutic Genes, Mahdi Zavvar, Sara Assadiasl, Narjes Soleimanifar, Fatemeh Dadgar Pakdel, Kamal Abdolmohammadi, Yousef Fatahi, Mohsen Abdolmaleki, Hamed Baghdadi, Lobat Tayebi, Mohammad Hossein Nicknam
Gene Therapy In Rheumatoid Arthritis: Strategies To Select Therapeutic Genes, Mahdi Zavvar, Sara Assadiasl, Narjes Soleimanifar, Fatemeh Dadgar Pakdel, Kamal Abdolmohammadi, Yousef Fatahi, Mohsen Abdolmaleki, Hamed Baghdadi, Lobat Tayebi, Mohammad Hossein Nicknam
School of Dentistry Faculty Research and Publications
Significant advances have been achieved in recent years to ameliorate rheumatoid arthritis (RA) in animal models using gene therapy approaches rather than biological treatments. Although biological agents serve as antirheumatic drugs with suppressing proinflammatory cytokine activities, they are usually accompanied by systemic immune suppression resulting from continuous or high systemic dose injections of biological agents. Therefore, gene transfer approaches have opened an interesting perspective to deliver one or multiple genes in a target‐specific or inducible manner for the sustained intra‐articular expression of therapeutic products. Accordingly, many studies have focused on gene transferring methods in animal models by using one of …
Recent Advancements In Aptamer-Bioconjugates: Sharpening Stones For Breast And Prostate Cancers Targeting, Saeid Maghsoudi, Bahareh Taghavi Shahraki, Navid Rabiee, Ronak Afshari, Yousef Fatahi, Rassoul Dinarvand, Sepideh Ahmadi, Mojtaba Bagherzadeh, Mohammad Rabiee, Lobat Tayebi, Mohammadreza Tahriri
Recent Advancements In Aptamer-Bioconjugates: Sharpening Stones For Breast And Prostate Cancers Targeting, Saeid Maghsoudi, Bahareh Taghavi Shahraki, Navid Rabiee, Ronak Afshari, Yousef Fatahi, Rassoul Dinarvand, Sepideh Ahmadi, Mojtaba Bagherzadeh, Mohammad Rabiee, Lobat Tayebi, Mohammadreza Tahriri
School of Dentistry Faculty Research and Publications
Breast and prostate cancers are common types of cancers with various strategies, such as chemotherapy and radiotherapy, for their therapy. Since these methods have undesired side effects and poor target affinity, neoteric strategies—known as aptamer-based smart drug delivery systems (SDDSs)—have been developed in recent years to overcome the obstacles of current treatment, and investigated for a clinical trial. The high affinity and versatility of aptamers for binding to the corresponding targets make them highly noticeable agents in the drug delivery domains. In addition to their exceptional benefits, aptamers are able to overcome tumor resistance because of their high selectivity and …
Billed And Paid Amounts For Preventive Procedures In Dental Medicaid, K. Wagner, Aniko Szabo, Elaye Okunseri, Christopher Okunseri
Billed And Paid Amounts For Preventive Procedures In Dental Medicaid, K. Wagner, Aniko Szabo, Elaye Okunseri, Christopher Okunseri
School of Dentistry Faculty Research and Publications
Objective:
To examine trends and variations in billed and paid amounts for preventive dental procedures by race/ethnicity, age, and sex in Wisconsin dental Medicaid.
Methods:
We analyzed data from the 2001 to 2013 Wisconsin Medicaid claims database for preventive dental procedures for children and adults. Billed and paid amounts for preventive dental procedures were aggregated over a visit and adjusted for inflation based on the Medical Care Consumer Price Index produced by the Bureau of Labor Statistics for 2013. Quantile regression was used to examine the trends over time and the effect of patient demographics.
Result:
At the 50th and …
Effect Of Biomimetic Mineralization On Enamel And Dentin: A Raman And Edx Analysis, Arndt Guentsch, Mina D. Fahmy, Contanze Wehrle, Sandor Nitzsche, Jürgen Popp, David C. Watts, Stefan Kranz, Christoph Krafft, Bernd W. Sigusch
Effect Of Biomimetic Mineralization On Enamel And Dentin: A Raman And Edx Analysis, Arndt Guentsch, Mina D. Fahmy, Contanze Wehrle, Sandor Nitzsche, Jürgen Popp, David C. Watts, Stefan Kranz, Christoph Krafft, Bernd W. Sigusch
School of Dentistry Faculty Research and Publications
Objective
To investigate the effect of an experimental biomimetic mineralization kit (BIMIN) on the chemical composition and crystallinity of caries-free enamel and dentin samples in vitro.
Methods
Enamel and dentin samples from 20 human teeth (10 for enamel; 10 for dentin) were divided into a control group without treatment and test samples with BIMIN treatment. Quantitative analysis of tissue penetration of fluoride, phosphate, and calcium was performed using energy-dispersive X-ray spectroscopy (EDX). Mineralization depth was measured by Raman spectroscopy probing the symmetric valence vibration near 960 cm−1 as a marker for crystallinity. EDX data was statistically analyzed using …
Temperature And Ph-Responsive Nano-Hydrogel Drug Delivery System Based On Lysine-Modified Poly (Vinylcaprolactam), Fatemeh Farjadian, Somayeh Rezaeifard, Mahsa Naeimi, Sahar Ghasemi, Soliman Mohammadi-Samani, Mark E. Welland, Lobat Tayebi
Temperature And Ph-Responsive Nano-Hydrogel Drug Delivery System Based On Lysine-Modified Poly (Vinylcaprolactam), Fatemeh Farjadian, Somayeh Rezaeifard, Mahsa Naeimi, Sahar Ghasemi, Soliman Mohammadi-Samani, Mark E. Welland, Lobat Tayebi
School of Dentistry Faculty Research and Publications
Background: Smart materials capable of responding to external stimuli are noteworthy candidates in designing drug delivery systems. In many of the recent research, temperature and pH have been recognized as the main stimulating factors in designing systems for anti-cancer drugs delivery systems.
Purpose: In this study, thermo and pH-responsive character of a nano-carrier drug delivery platform based on lysine modified poly (vinylcaprolactam) hydrogel conjugated with doxorubicin was assessed.
Methods: Poly (vinylcaprolactam) cross-linked with poly (ethyleneglycol) diacrylate was prepared via RAFT polymerization, and the prepared structure was linked with lysine through ring-opening. The anti-cancer drug doxorubicin, was linked to lysine moiety …
Effect Of Finish Line Design And Metal Alloy On The Marginal And Internal Gaps Of Selective Laser Melting Printed Copings, Adel Al Maaz, Geoffrey A. Thompson, Carl Drago, Hongseok An, David W. Berzins
Effect Of Finish Line Design And Metal Alloy On The Marginal And Internal Gaps Of Selective Laser Melting Printed Copings, Adel Al Maaz, Geoffrey A. Thompson, Carl Drago, Hongseok An, David W. Berzins
School of Dentistry Faculty Research and Publications
Statement of problem
Selective laser melting (SLM) technology has been introduced for printing metal dental restorations from Co-Cr base alloys or Au-Pt high noble alloys. However, information regarding the fit of restorations fabricated by using this technique is limited.
Purpose
The purpose of this in vitro study was to determine the effect of 3 different finish line designs on the marginal and internal gaps of metal copings made from a base (Co-Cr), high noble (Au-Pd-Ag), and noble alloy (Co-Pd) by using the SLM technology.
Material and methods
Three Ivorine right maxillary central incisors were prepared with a chamfer, deep chamfer, …
Stimulus-Responsive Polymeric Nanogels As Smart Drug Delivery Systems, Sakineh Hajebi, Navid Rabiee, Mojtaba Bagherzadeh, Sepideh Ahmadi, Mohammad Rabiee, Hossein Roghani-Mamaqani, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin
Stimulus-Responsive Polymeric Nanogels As Smart Drug Delivery Systems, Sakineh Hajebi, Navid Rabiee, Mojtaba Bagherzadeh, Sepideh Ahmadi, Mohammad Rabiee, Hossein Roghani-Mamaqani, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin
School of Dentistry Faculty Research and Publications
Nanogels are three-dimensional nanoscale networks formed by physically or chemically cross-linking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or external stimuli such as pH, temperature, light and redox, thus resulting in the controlled release of loaded drugs. This “smart” targeting ability prevents drug accumulation in non-target tissues and …
Effects Of Dental Composite Resin Monomers On Dental Pulp Cells, Thomas R. Schneider, Roxan Hakami-Tafreshi, Alexandra Tomasino-Perez, Lobat Tayebi, Doug Lobner
Effects Of Dental Composite Resin Monomers On Dental Pulp Cells, Thomas R. Schneider, Roxan Hakami-Tafreshi, Alexandra Tomasino-Perez, Lobat Tayebi, Doug Lobner
School of Dentistry Faculty Research and Publications
Methacrylate monomers found in many dental materials cause toxicity to dental pulp cells but the mechanism of the toxicity is poorly understood. We used cultured human dental pulp cells to test the effects of three commonly used monomers; bisphenol-A-glycidyl methacrylate (Bis-GMA), urethane dimethacrylate (UDMA), and triethyleneglycol dimethacrylate (TEGDMA). The order of toxicity was Bis-GMA>UDMA>TEGDMA. The toxicity correlated inversely with cystine uptake, with TEGDMA stimulating uptake and BisGMA and UDMA inhibiting uptake. Bis-GMA and UDMA induced oxidative stress, while TEGDMA did not. Toxicity correlated poorly with glutathione levels, as all compounds decreased cellular glutathione. TEGDMA is less toxic than …
Comparison Of Gingival Retraction Materials Using A New Gingival Sulcus Model, Marco Dederichs, Mina D. Fahmy, Harald Kuepper, Arndt Guentsch
Comparison Of Gingival Retraction Materials Using A New Gingival Sulcus Model, Marco Dederichs, Mina D. Fahmy, Harald Kuepper, Arndt Guentsch
School of Dentistry Faculty Research and Publications
Purpose
To investigate the pressure generated by different retraction materials using a novel gingival sulcus model.
Materials and Methods
A gingival sulcus model was made using a polymer frame filled with silicon. A pressure sensor and a sulcus‐fluid simulation were embedded into the silicon chamber to evaluate the pressure generated by different retraction materials. Six sizes of Ultrapak retraction cords (Ultradent, sizes #000 ‐ 3), 4 retraction pastes (Expazen, Expasyl, Acteon, Access Edge, Traxodent) and 2 retraction gels (Sulcus Blue, Racegel) were analyzed. The mean and median pressure, interquartile range, and standard deviation (SD) of n = 10 repeated measurements …
Bicyclic Peptides: Types, Synthesis And Applications, Shahrzad Ahangarzadeh, Mohammad M. Kanafi, Simzar Hosseinzadeh, Ahad Mokhtarzadeh, Mahmood Barati, Javad Ranjbari, Lobat Tayebi
Bicyclic Peptides: Types, Synthesis And Applications, Shahrzad Ahangarzadeh, Mohammad M. Kanafi, Simzar Hosseinzadeh, Ahad Mokhtarzadeh, Mahmood Barati, Javad Ranjbari, Lobat Tayebi
School of Dentistry Faculty Research and Publications
Bicyclic peptides form one of the most promising platforms for drug development owing to their biocompatibility, similarity and chemical diversity to proteins, and they are considered as a possible practical tool in various therapeutic and diagnostic applications. Bicyclic peptides are known to have the capability of being employed as an effective alternative to complex molecules, such as antibodies, or small molecules. This review provides a summary of the recent progress on the types, synthesis and applications of bicyclic peptides. More specifically, natural and synthetic bicyclic peptides are introduced with their different production methods and relevant applications, including drug targeting, imaging …
Prevalence Of Molar-Incisor Hypomineralization In Milwaukee, Wisconsin, Usa: A Pilot Study, Megan Davenport, Andrew D. Welles, Matina V. Angelopoulou, Cesar D. Gonzalez, Christopher Okunseri, Lori Barbeau, Naveen K. Bansal, Rodney Vergotine, Brian D. Hodgson
Prevalence Of Molar-Incisor Hypomineralization In Milwaukee, Wisconsin, Usa: A Pilot Study, Megan Davenport, Andrew D. Welles, Matina V. Angelopoulou, Cesar D. Gonzalez, Christopher Okunseri, Lori Barbeau, Naveen K. Bansal, Rodney Vergotine, Brian D. Hodgson
School of Dentistry Faculty Research and Publications
Purpose: This pilot study investigated the prevalence of Molar-Incisor Hypomineralization (MIH) in third-grade school children in Milwaukee Wisconsin, USA.
Methods: A convenience sample of third-grade school children in the Milwaukee Public School System (MPS) participated in the study. Calibrated examiners trained on the European Academy of Paediatric Dentistry (EAPD) MIH recommendations examined the children between December 1, 2014 and June 30, 2015. Children were examined at their schools using a flashlight and mirror after receiving consent from parents/caregivers and assent from each child. Findings were recorded onto a standardized form by one of five trained examiners. Summary statistics were calculated, …
Association Of Food Insecurity With Early Childhood Caries, Matina V. Angelopoulou, S. D. Shanti, Cesar Gonzalez, Ashley Love, Jeffrey Chaffin
Association Of Food Insecurity With Early Childhood Caries, Matina V. Angelopoulou, S. D. Shanti, Cesar Gonzalez, Ashley Love, Jeffrey Chaffin
School of Dentistry Faculty Research and Publications
Objectives
The aim of this study was to examine the association of food insecurity on the prevalence of dental caries in preschool children.
Methods
Eighty-two children, aged 12-71 months old, from the Marquette University School of Dentistry Community South Clinic and their caregivers participated in this cross-sectional study. Following informed consent, parents completed the validated six-item US Department of Agriculture food insecurity questionnaire and questions regarding demographic information and family structure. Upon clinical examination caries was recorded using the decayed, missing, filled teeth (dmft) index based on the International Caries Detection and Assessment System criteria.
Results
The correlation between dmft …
The Effectiveness Of Different Attachment Systems Maxillary And Mandibular Implant Overdentures, Gary L. Stafford
The Effectiveness Of Different Attachment Systems Maxillary And Mandibular Implant Overdentures, Gary L. Stafford
School of Dentistry Faculty Research and Publications
Data sources Cochrane Oral Health's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, the US National Institutes of Health Ongoing Trials Register (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform.
Study selection Randomised controlled trials (RCTs), including cross-over trials on maxillary or mandibular implant overdentures with different attachment systems with at least one-year follow-up were considered. There were no restrictions on language or date of publication.
Data extraction and synthesis Data were abstracted by four reviewers with risk of bias being assessed using the Cochrane tool. Data were combined using a fixed effects …
Effect Of Airborne-Particle Abrasion On 3-Dimensional Surface Roughness And Characteristic Failure Load Of Fiber-Reinforced Posts, Georgios Maroulakos, Michael W. Wanserski, Michelle M. Wanserski, Ethan J. Schuler, Colin P. Egan, Geoffrey A. Thompson
Effect Of Airborne-Particle Abrasion On 3-Dimensional Surface Roughness And Characteristic Failure Load Of Fiber-Reinforced Posts, Georgios Maroulakos, Michael W. Wanserski, Michelle M. Wanserski, Ethan J. Schuler, Colin P. Egan, Geoffrey A. Thompson
School of Dentistry Faculty Research and Publications
Statement of problem
Debonding is the most common complication of fiber-reinforced posts (FRPs). Airborne-particle abrasion (APA) has been suggested to increase resin cement adhesion to the surface of FRPs. However, which abrasion protocol is the most favorable is unclear.
Purpose
The purpose of this in vitro study was to compare the surface roughness and characteristic failure load of three FRP systems following different APA protocols.
Material and methods
A total of 150 posts from 3 manufacturers (glass FRP, quartz FRP, and zirconia-enriched glass FRP) were randomly assigned to different surface treatments (NT: no treatment—control; E0: cleaned with 96% ethanol solution; …
Primary Molar Pulpotomies With Different Hemorrhage Control Agents And Base Materials: A Randomized Clinical Trial, G. Atasever, T. I. Keceli, Serdar Uysal, H. Cem Güngör, S. Olmez
Primary Molar Pulpotomies With Different Hemorrhage Control Agents And Base Materials: A Randomized Clinical Trial, G. Atasever, T. I. Keceli, Serdar Uysal, H. Cem Güngör, S. Olmez
School of Dentistry Faculty Research and Publications
Objective: To evaluate the clinical and radiographical success of primary molar pulpotomies which used 15.5% ferric sulfate (FS) or 1.25% sodium hypochlorite (NaOCl) for hemostasis and zinc oxide-eugenol (ZOE) and calcium hydroxide (CH) pastes as base materials.
Methods: In 29 healthy children, 80 primary molars were randomly allocated to one of the study groups: Group 1: FS-ZOE, Group 2: FS-CH, Group 3: NaOCl-ZOE, and Group 4: NaOCl-CH. After hemostasis with the respective solutions, pulp stumps and floor of the pulp chambers were covered with either ZOE or CH pastes. All teeth were restored with stainless steel crowns. Follow-up examinations were …
Mathematical Modeling Of Oxygen Transfer In Porous Scaffolds For Stem Cell Growth: The Effects Of Porosity, Cell Type, Scaffold Architecture And Cell Distribution, Saeid Atashrouz, Ali Hatampoor, Amir Yadegari, Hamed Ghasemi, Lobat Tayebi, Morteza Rasoulianboroujeni
Mathematical Modeling Of Oxygen Transfer In Porous Scaffolds For Stem Cell Growth: The Effects Of Porosity, Cell Type, Scaffold Architecture And Cell Distribution, Saeid Atashrouz, Ali Hatampoor, Amir Yadegari, Hamed Ghasemi, Lobat Tayebi, Morteza Rasoulianboroujeni
School of Dentistry Faculty Research and Publications
Oxygen plays a key role in human mesenchymal stem cell growth. Without adequate oxygen (hypoxic condition), cells are not able to survive, proliferate, and migrate. The objective of the present study is to investigate oxygen transfer through the cell-seeded scaffolds stored in static or dynamic bioreactors using a mathematical model. The effects of porosity, cell type, scaffold architecture and cell distribution as potential effective parameters on oxygen transfer kinetics were examined. The results suggest the substantial effect of porosity and cell type on the oxygen concentration within the scaffold compared to scaffold architecture (homogeneous vs. gradient). The obtained data …
Edta-Modified Mesoporous Silica As Supra Absorbent Of Copper Ions With Novel Approach As An Antidote Agent In Copper Toxicity, Elham Rafiee Taqanaki, Reza Heidari, Mohammad Monfared, Lobat Tayebi, Amir Azadi, Fatemeh Farjadian
Edta-Modified Mesoporous Silica As Supra Absorbent Of Copper Ions With Novel Approach As An Antidote Agent In Copper Toxicity, Elham Rafiee Taqanaki, Reza Heidari, Mohammad Monfared, Lobat Tayebi, Amir Azadi, Fatemeh Farjadian
School of Dentistry Faculty Research and Publications
Purpose: Mesoporous silica (MS) have been considered as a biocompatible compound and found to have various pharmaceutical applications. Recently, novel approaches in applications of MS as antidote agents were introduced. In this study, the capacity of ethylenediaminetetraacetic acid modified mesoporous silica (MS-EDTA) was evaluated in in vitro and in vivo adsorption of copper (Cu). Methods: The MS-EDTA was characterized by fourier transform infrared (FT-IR) and X-ray diffraction, while surface area was determined by N2 adsorption–desorption technique. Morphological studies were observed by high resolution-transmission electron microscopy and field emission-scanning electron microscopy and the sizes were determined by dynamic light scattering. …
Applications Of 3d Printing On Craniofacial Bone Repair: A Systematic Review, Michael Maroulakos, George Kamperos, Lobat Tayebi, Demetrios J. Halazonetis, Yijin Ren
Applications Of 3d Printing On Craniofacial Bone Repair: A Systematic Review, Michael Maroulakos, George Kamperos, Lobat Tayebi, Demetrios J. Halazonetis, Yijin Ren
School of Dentistry Faculty Research and Publications
Objectives
Three-dimensional (3D) bioprinting, a method derived from additive manufacturing technology, is a recent and ongoing trend for the construction of 3D volumetric structures. The purpose of this systematic review is to summarize evidence from existing human and animal studies assessing the application of 3D printing on bone repair and regeneration in the craniofacial region.
Data & sources
A rigorous search of all relevant clinical trials and case series was performed, based on specific inclusion and exclusion criteria. The search was conducted in all available electronic databases and sources, supplemented by a manual search, in December 2017.
Study selection
43 …
Influence Of Apical Preparation Size On Effective Conventional Irrigation In The Apical Third: A Scanning Electron Microscopic Study, Seth Butcher, Abeer Mansour, Mohamed Ibrahim
Influence Of Apical Preparation Size On Effective Conventional Irrigation In The Apical Third: A Scanning Electron Microscopic Study, Seth Butcher, Abeer Mansour, Mohamed Ibrahim
School of Dentistry Faculty Research and Publications
Objective: This study aimed to investigate the relationship between final apical preparation size and smear layer removal in the apical third using conventional irrigation in mandibular bicuspids.
Methods: A total of 66 extracted human mandibular bicuspids with comparable root canal morphology were equally divided into five experimental groups and a control group (n=11). Based on their experimental group, samples were instrumented up to size 25, 30, 35, 40, or 45 with 0.04 taper using 2.5% sodium hypochlorite (NaOCl) as the irrigant. Final irrigation was performed with 17% EDTA followed by 2.5% NaOCl. The control group was instrumented up to size …
Early Condylectomy: Biological Considerations, Diego Fernando López, Juliana Ruiz Botero, Luis Eduardo Almeida
Early Condylectomy: Biological Considerations, Diego Fernando López, Juliana Ruiz Botero, Luis Eduardo Almeida
School of Dentistry Faculty Research and Publications
Objective: To describe the early treatment of two patients with unilateral condylar hyperplasia (UCH) diagnosis and therapeutic surgical protocol (early condylectomy) supported by the current biological knowledge about the development and repair of mandibular condyle cartilage (MCC). Methods: Review of the literature and two case description of the treatment. The two patients were girls, 12 and 13 year old. The follow up period was of 3 years. SPECT diagnostic, radiographic, photographic and tomographic images are presented. Results: The literature summarized provides biological basis favoring the early treatment of UCH. The two cases were treated with the same surgical protocol obtaining …
Biomaterials Evaluation: Conceptual Refinements And Practical Reforms, Reza Masaeli, Kavosh Zandsalimi, Lobat Tayebi
Biomaterials Evaluation: Conceptual Refinements And Practical Reforms, Reza Masaeli, Kavosh Zandsalimi, Lobat Tayebi
School of Dentistry Faculty Research and Publications
Regarding the widespread and ever-increasing applications of biomaterials in different medical fields, their accurate assessment is of great importance. Hence the safety and efficacy of biomaterials is confirmed only through the evaluation process, the way it is done has direct effects on public health. Although every biomaterial undergoes rigorous premarket evaluation, the regulatory agencies receive a considerable number of complications and adverse event reports annually. The main factors that challenge the process of biomaterials evaluation are dissimilar regulations, asynchrony of biomaterials evaluation and biomaterials development, inherent biases of postmarketing data, and cost and timing issues. Several pieces of evidence indicate …
Culture Of Dental Pulp Stem Cells On Nanoporous Alumina Substrates Modified By Carbon Nanotubes, Ameneh Alizadeh, Amir Razmjou, Mehrorang Ghaedi, Ramin Jannesar, Fahimeh Tabatabaei, Vahid Pezeshkpour, Lobat Tayebi
Culture Of Dental Pulp Stem Cells On Nanoporous Alumina Substrates Modified By Carbon Nanotubes, Ameneh Alizadeh, Amir Razmjou, Mehrorang Ghaedi, Ramin Jannesar, Fahimeh Tabatabaei, Vahid Pezeshkpour, Lobat Tayebi
School of Dentistry Faculty Research and Publications
Purpose: Alumina substrates are one of the commonly used scaffolds applied in cell culture, but in order to prevent formation of biofilm on the alumina substrate, these substrates are modified with carbon nanotube. Methods: The alumina substrate was made by a two-step anodization method and was then modified with carbon nanotubes by simple chemical reaction. The substrates were characterized with FTIR, SEM, EDX, 3D laser scanning digital microscope, contact angle (CA) and surface free energy (SFE). To determine how this modification influences the reduction of biofilm, biofilm of two various bacteria, Escherichia coli (E.coli) and Staphylococcus aureus ( …
Ankylosing Spondylitis And Mesenchymal Stromal/Stem Cell Therapy: A New Therapeutic Approach, Kamal Abdolmohammadi, Fatemeh Dadgar Pakdel, Hamideh Aghaei, Sara Assadiasl, Yousef Fatahi, Negin Hosseini Rouzbahani, Alireza Rezaiemanesh, Masoud Soleimani, Lobat Tayebi, Mohammad Hossein Nicknam
Ankylosing Spondylitis And Mesenchymal Stromal/Stem Cell Therapy: A New Therapeutic Approach, Kamal Abdolmohammadi, Fatemeh Dadgar Pakdel, Hamideh Aghaei, Sara Assadiasl, Yousef Fatahi, Negin Hosseini Rouzbahani, Alireza Rezaiemanesh, Masoud Soleimani, Lobat Tayebi, Mohammad Hossein Nicknam
School of Dentistry Faculty Research and Publications
Ankylosing spondylitis (AS) is an inflammatory rheumatoid disease categorized within spondyloarthropathies (SpA) and manifested by chronic spinal arthritis. Several innate and adaptive immune cells and secreted-mediators have been indicated to play a role in AS pathogenesis. Considering the limitations of current therapeutic approaches (NSAIDs, glucocorticoids, DMARDs and biologic drugs), finding new treatments with fewer side effects and high therapeutic potentials are required in AS. Mesenchymal stem cells (MSCs) with considerable immunomodulatory and regenerative properties could be able to attenuate the inflammatory responses and help tissue repair by cell-to-cell contact and secretion of soluble factors. Moreover, MSCs do not express HLA-DR, …