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Full-Text Articles in Dentistry

Efficacy Of Stem Cell Allograft In Maxillary Sinus Bone Regeneration: A Randomized Controlled Clinical And Blinded Histomorphometric Study, Josh Whitt, Mohanad Al-Sabbagh, Dolph R. Dawson Iii, Ehab Shehata, Moly Housley-Smith, Alejandro G. Villasante Tezanos, Ahmad Kutkut Jun 2020

Efficacy Of Stem Cell Allograft In Maxillary Sinus Bone Regeneration: A Randomized Controlled Clinical And Blinded Histomorphometric Study, Josh Whitt, Mohanad Al-Sabbagh, Dolph R. Dawson Iii, Ehab Shehata, Moly Housley-Smith, Alejandro G. Villasante Tezanos, Ahmad Kutkut

Oral Health Practice Faculty Publications

Purpose: This study aimed to evaluate the quality and quantity of newly generated bone in the maxillary sinus grafted with stem cell-based allograft material.

Methods: This study was a single site, prospective, blinded, randomized, and controlled clinical trial. Eleven subjects with 18 edentulous posterior maxillary sites requiring sinus augmentation for delayed implant placement using a lateral window approach were enrolled. At the time of sinus augmentation, test sinus was grafted with stem cell-based allograft (Osteocel Plus; NuVasive Therapeutics), while the control sinus was grafted with conventional cortico-cancellous allograft (alloOss; ACE Surgical). Cone beam computer tomography (CBCT) scan was taken before …


Bioerodible Calcium Sulfate Bone Grafting Substitutes With Tailored Drug Delivery Capabilities, Bryan R. Orellana Jan 2014

Bioerodible Calcium Sulfate Bone Grafting Substitutes With Tailored Drug Delivery Capabilities, Bryan R. Orellana

Theses and Dissertations--Biomedical Engineering

Bone regeneration or augmentation is often required prior to or concomitant with implant placement. With the limitations of many existing technologies, a biologically compatible synthetic bone grafting substitute that is osteogenic, bioerodible, and provides spacing-making functionality while acting as a drug delivery vehicle for bioactive molecules could provide an alternative to ‘gold standard’ techniques.

In the first part of this work, calcium sulfate (CS) space-making synthetic bone grafts with uniformly embedded poly(β-amino ester) (PBAE) biodegradable hydrogel particles was developed to allow controlled release of bioactive agents. The embedded gel particles’ influence on the physical and chemical characteristics of CS was …