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Full-Text Articles in Dentistry
Differential Microrna Expression Of Mir-21 And Mir-155 With Oral Cancer Extracellular Vesicles In Response To Melationin, Matthew Hunsaker, Greta Barba, Karl Kingsley, Katherine M. Howard
Differential Microrna Expression Of Mir-21 And Mir-155 With Oral Cancer Extracellular Vesicles In Response To Melationin, Matthew Hunsaker, Greta Barba, Karl Kingsley, Katherine M. Howard
Dental Medicine Faculty Publications
Objective: Extracellular vesicles derived from oral cancer cells, which include Exosomes and Oncosomes, are membranous vesicles secreted into the surrounding extracellular environment. These extracellular vesicles can regulate and modulate oral squamous cell carcinoma (OSCC) progression through the horizontal transfer of bioactive molecules including proteins, lipids and microRNA (miRNA). The primary objective of this study was to examine the potential to isolate and evaluate extracellular vesicles (including exosomes) from various oral cancer cell lines and to explore potential differences in miRNA content. Methods: The OSCC cell lines SCC9, SCC25 and CAL27 were cultured in DMEM containing 10% exosome-free fetal bovine serum. …
Oral Cancer Awareness Among University Students From Karachi, Pakistan, Dnyanesh Limaye, Patrick Ziesenis, Vaidehi Limaye, Mansoor Ahmad, Farah Saeed, Mahboob Alam, Ramla Rizvi, Atul Kapadi, Sushama Sathe, Gerhard Fortwengel
Oral Cancer Awareness Among University Students From Karachi, Pakistan, Dnyanesh Limaye, Patrick Ziesenis, Vaidehi Limaye, Mansoor Ahmad, Farah Saeed, Mahboob Alam, Ramla Rizvi, Atul Kapadi, Sushama Sathe, Gerhard Fortwengel
Section of Dental-Oral Maxillofacial Surgery
Background: Oral cancers (OC) are malignant lesions occurring in the oral cavity that include squamous cell carcinomas (SCC), salivary gland and odontogenic neoplasms. Even though it is the eighth most common malignancy globally but in Pakistan it is the second commonest type of cancer. Lack of awareness about ill-effects of preventable risk factors of oral cancer increases the burden of disease due to the associated high cost of treatment, permanent impairment and high mortality. Hence, awareness can be very helpful in prevention, control and early diagnosis of oral cancer.
Methods: A cross-sectional study was carried out among university students from …