Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Gerontology (2)
- Medical Sciences (2)
- Medical Specialties (2)
- Social and Behavioral Sciences (2)
- Sociology (2)
-
- Amino Acids, Peptides, and Proteins (1)
- Biochemical Phenomena, Metabolism, and Nutrition (1)
- Chemical and Pharmacologic Phenomena (1)
- Clinical Epidemiology (1)
- Clinical and Medical Social Work (1)
- Cognitive Neuroscience (1)
- Community Health (1)
- Counseling Psychology (1)
- Epidemiology (1)
- Genetic Phenomena (1)
- Geriatric Nursing (1)
- Geriatrics (1)
- Health Services Research (1)
- Life Sciences (1)
- Marriage and Family Therapy and Counseling (1)
- Medicine and Health (1)
- Mental and Social Health (1)
- Neuroscience and Neurobiology (1)
- Nursing (1)
- Other Chemicals and Drugs (1)
- Other Mental and Social Health (1)
- Other Public Health (1)
- Pediatrics (1)
- Institution
- Publication
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Chemicals and Drugs
Age Drives Distortion Of Brain Metabolic, Vascular And Cognitive Functions, And The Gut Microbiome, Jared D. Hoffman, Ishita Parikh, Stefan J. Green, George Chlipala, Robert P. Mohney, Mignon Keaton, Bjoern Bauer, Anika M. S. Hartz, Ai-Ling Lin
Age Drives Distortion Of Brain Metabolic, Vascular And Cognitive Functions, And The Gut Microbiome, Jared D. Hoffman, Ishita Parikh, Stefan J. Green, George Chlipala, Robert P. Mohney, Mignon Keaton, Bjoern Bauer, Anika M. S. Hartz, Ai-Ling Lin
Sanders-Brown Center on Aging Faculty Publications
Advancing age is the top risk factor for the development of neurodegenerative disorders, including Alzheimer’s disease (AD). However, the contribution of aging processes to AD etiology remains unclear. Emerging evidence shows that reduced brain metabolic and vascular functions occur decades before the onset of cognitive impairments, and these reductions are highly associated with low-grade, chronic inflammation developed in the brain over time. Interestingly, recent findings suggest that the gut microbiota may also play a critical role in modulating immune responses in the brain via the brain-gut axis. In this study, our goal was to identify associations between deleterious changes in …
A Descriptive Study Of The Elderly In California Substance Abuse Treatment Programs, David Berenschot
A Descriptive Study Of The Elderly In California Substance Abuse Treatment Programs, David Berenschot
Electronic Theses, Projects, and Dissertations
As gerontologists may know, there are a great deal of studies and a variety of academic literature on the misuse of alcohol and prescription medication amongst the elderly population. While there is a plethora of information on alcohol and prescription misuse, there is little reported data about the prevalence of other substance misuse experienced by this population. This study aims to help to fill that gap in the data by using quantitative methods to describe the scope of substance abuse of individuals 55-years or older. This study utilizes data from the Treatment Data Set Admission (TEDS-A). The TEDS-A is a …
Age-Dependent Absolute Abundance Of Hepatic Carboxylesterases (Ces1 And Ces2) By Lc-Ms/Ms Proteomics: Application To Pbpk Modeling Of Oseltamivir In Vivo Pharmacokinetics In Infants., Mikael Boberg, Marc Vrana, Aanchal Mehrotra, Robin E. Pearce, Andrea Gaedigk, Deepak Kumar Bhatt, J Steven Leeder, Bhagwat Prasad
Age-Dependent Absolute Abundance Of Hepatic Carboxylesterases (Ces1 And Ces2) By Lc-Ms/Ms Proteomics: Application To Pbpk Modeling Of Oseltamivir In Vivo Pharmacokinetics In Infants., Mikael Boberg, Marc Vrana, Aanchal Mehrotra, Robin E. Pearce, Andrea Gaedigk, Deepak Kumar Bhatt, J Steven Leeder, Bhagwat Prasad
Manuscripts, Articles, Book Chapters and Other Papers
The age-dependent absolute protein abundance of carboxylesterase (CES) 1 and CES2 in human liver was investigated and applied to predict infant pharmacokinetics (PK) of oseltamivir. The CES absolute protein abundance was determined by liquid chromatography-tandem mass spectrometry proteomics in human liver microsomal and cytosolic fractions prepared from tissue samples obtained from 136 pediatric donors and 35 adult donors. Two surrogate peptides per protein were selected for the quantification of CES1 and CES2 protein abundance. Purified CES1 and CES2 protein standards were used as calibrators, and the heavy labeled peptides were used as the internal standards. In hepatic microsomes, CES1 and …