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Ethnic Variations In Paraoxonase1 Polymorphism In The Malaysian Population, Rozaida @ Poh Yuen Ying
Ethnic Variations In Paraoxonase1 Polymorphism In The Malaysian Population, Rozaida @ Poh Yuen Ying
Rozaida @ Poh Yuen Ying
The role of high-density lipoprotein associated paraoxonase (PON) 1 in protection against oxidative stress associated with the development of complications in diabetes mellitus has been reported. Variations in the PON1 gene, 55LM and 192QR have been described in different populations. These variations are known to be risk factors for heart disease, especially the L and R alleles. We have investigated the prevalence of both polymorphisms in the Malaysian population comprising the three major ethnic groups: Malay, Chinese and Indian, using polymerase chain reaction followed by restriction endonuclease digestion. The results show the pooled frequencies of L and R alleles were …