Chemicals and Drugs Commons^™

Effects Of A Selective Cannabinoid Cb2 Agonist And Antagonist On Intravenous Nicotine Self Administration And Reinstatement Of Nicotine Seeking, Islam Gamaleddin, Alexander Zvonok, Alexandros Makriyannis, Steven Goldberg, Bernard Le Foll

Alexander Zvonok

Over the last decade there have been significant advances in the discovery and understanding of the cannabinoid system along with the development of pharmacologic tools that modulate its function. Characterization of the crosstalk between nicotine addiction and the cannabinoid system may have significant implications on our understanding of the neurobiological mechanisms underlying nicotine dependence. Two types of cannabinoid receptors (CB1 and CB2) have been identified. CB1 receptors are expressed in the brain and modulate drug taking and drug seeking for various drugs of abuse, including nicotine. CB2 receptors have been recently identified in the brain and have been proposed to …