Open Access. Powered by Scholars. Published by Universities.®
- Keyword
- Publication
Articles 1 - 3 of 3
Full-Text Articles in Chemicals and Drugs
Effects Of Angiotensin 1-7 On The Actions Of Angiotensin Ii In The Renal And Mesenteric Vasculature Of Hypertensive And Streptozotocin-Induced Diabetic Rats, Mohd Rais Mustafa, Murugan Dharmani, Francis I. Achike, Meng-Kwoon Sim
Effects Of Angiotensin 1-7 On The Actions Of Angiotensin Ii In The Renal And Mesenteric Vasculature Of Hypertensive And Streptozotocin-Induced Diabetic Rats, Mohd Rais Mustafa, Murugan Dharmani, Francis I. Achike, Meng-Kwoon Sim
Mohd Rais Mustafa
Angiotensin 1-7, a heptapeptide derived from metabolism of either angiotensin I or angiotensin II, is a biologically active peptide of the renin–angiotensin system. The present study investigated the effect of angiotensin 1-7 on the vasopressor action of angiotensin II in the renal and mesenteric vasculature of Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHR) and streptozotocin-induced diabetic rats. Angiotensin II-induced dose-dependent vasoconstrictions in the renal vasculature. The pressor response was enhanced in the SHR and reduced in the streptozotocin-diabetic rat compared to WKY rats. Angiotensin 1-7 attenuated the angiotensin II pressor responses in the renal vasculature of WKY and SHR rats. …
Ethnic Variations In Paraoxonase1 Polymorphism In The Malaysian Population, Rozaida @ Poh Yuen Ying
Ethnic Variations In Paraoxonase1 Polymorphism In The Malaysian Population, Rozaida @ Poh Yuen Ying
Rozaida @ Poh Yuen Ying
The role of high-density lipoprotein associated paraoxonase (PON) 1 in protection against oxidative stress associated with the development of complications in diabetes mellitus has been reported. Variations in the PON1 gene, 55LM and 192QR have been described in different populations. These variations are known to be risk factors for heart disease, especially the L and R alleles. We have investigated the prevalence of both polymorphisms in the Malaysian population comprising the three major ethnic groups: Malay, Chinese and Indian, using polymerase chain reaction followed by restriction endonuclease digestion. The results show the pooled frequencies of L and R alleles were …
Modulation Of Vascular Reactivity In Normal, Hypertensive And Diabetic Rat Aortae By A Non-Antioxidant Flavonoid, Mohd Rais Mustafa, Macha Ajay, Fracis I. Achike
Modulation Of Vascular Reactivity In Normal, Hypertensive And Diabetic Rat Aortae By A Non-Antioxidant Flavonoid, Mohd Rais Mustafa, Macha Ajay, Fracis I. Achike
Mohd Rais Mustafa
In this study, we report the effects of a non-antioxidant flavonoid flavone on vascular reactivity in Wistar–Kyoto (WKY) rat isolated aortae. Whether flavone directly modulates vascular reactivity in spontaneously hypertensive rat (SHR) and streptozotocin-induced diabetic-WKY rat isolated aortae was also determined. Thoracic aortic rings were mounted in organ chambers and exposed to various drug treatments in the presence of flavone or its vehicle (DMSO), which served as control. Pretreatment with flavone enhanced relaxant effects to endothelium-dependent vasodilator acetylcholine (ACh) and attenuated contractile effects to 1-receptor agonist phenylephrine (PE) in WKY aortae compared to those observed in control aortic rings. Flavone …