Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Anatomy
The Role Of Sulfatide In The Development And Maintenance Of The Nodal And Paranodal Domains In The Peripheral Nervous System, Heather Herman
The Role Of Sulfatide In The Development And Maintenance Of The Nodal And Paranodal Domains In The Peripheral Nervous System, Heather Herman
Theses and Dissertations
Sulfatide is a galactolipid and a major lipid component of the myelin sheath. Its production is catalyzed by the enzyme cerebroside sulfotransferase (CST). To determine the functions of sulfatide, the gene encoding CST was genetically disrupted resulting in mice incapable of sulfatide synthesis. Using these mice, it has been shown in the central nervous system (CNS) that sulfatide is essential for normal myelin synthesis and stability even though the onset of myelination is not impaired. Additionally, proper initial clustering of paranodal proteins and cluster maintenance of nodal proteins is impaired suggesting that paranodal domains are important for long-term node stability. …
Sulfatide Is Required For Organization Of The Paranode In The Myelinated Axon In The Peripheral Nervous System, Eva Kwong
Theses and Dissertations
Myelin facilitates the timely, efficient conduction of action potentials along axons. Made by Schwann cells (SCs) in the PNS, myelin is unique in that it is composed of a high percentage of lipids, particularly galactolipids. Sulfatide, one such galactolipid, is made by cerebroside sulfotransferase (CST) and has been shown to play a role in organizing paranodal domains in myelinated axons. However less is known regarding the involvement of sulfatide in the establishment and maintenance of the node, of particular interest as it is responsible for the potentiation of action potentials along the axon. Using immunohistochemical and, to a lesser extent, …
Discovery And Initial Characterizations Of Neurofascin 155 High And Neurofascin 155 Low, Anthony Pomicter
Discovery And Initial Characterizations Of Neurofascin 155 High And Neurofascin 155 Low, Anthony Pomicter
Theses and Dissertations
This thesis contains the findings from four years of research regarding an oligodendrocyte protein named neurofascin 155. The role of this protein in maintaining adhesion between the myelin sheath of oligodendrocytes and the axons of neurons has become well established in recent years and the research presented here has revealed that while western blots have previously shown one protein/band representing neurofascin 155, there are two proteins/bands. These two proteins have been named neurofascin 155 high and neurofascin 155 low due to their previous inclusion in the single band. The work leading up to their discovery, findings, and the relevance of …